Peptidyl arginine deiminase 2 (PADI2)-mediated arginine citrullination modulates transcription in cancer
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- dc.contributor.author Beato, Miguel
- dc.contributor.author Sharma, Priyanka
- dc.date.accessioned 2020-04-15T12:45:11Z
- dc.date.available 2020-04-15T12:45:11Z
- dc.date.issued 2020
- dc.description.abstract Protein arginine deimination leading to the non-coded amino acid citrulline remains a key question in the field of post-translational modifications ever since its discovery by Rogers and Simmonds in 1958. Citrullination is catalyzed by a family of enzymes called peptidyl arginine deiminases (PADIs). Initially, increased citrullination was associated with autoimmune diseases, including rheumatoid arthritis and multiple sclerosis, as well as other neurological disorders and multiple types of cancer. During the last decade, research efforts have focused on how citrullination contributes to disease pathogenesis by modulating epigenetic events, pluripotency, immunity and transcriptional regulation. However, our knowledge regarding the functional implications of citrullination remains quite limited, so we still do not completely understand its role in physiological and pathological conditions. Here, we review the recently discovered functions of PADI2-mediated citrullination of the C-terminal domain of RNA polymerase II in transcriptional regulation in breast cancer cells and the proposed mechanisms to reshape the transcription regulatory network that promotes cancer progression.
- dc.description.sponsorship This work was supported by Spanish MEC (SAF2016–75006), the Catalan Government (2017–2019 SGR 747_MBeato), and the European Research Council Synergy Grant “4DGenome” (609989). Also, we acknowledge the support of the Spanish Ministry of Economy and Competitiveness, “Centro de Excelencia Severo Ochoa” and the CERCA Programme/Generalitat de Catalunya”
- dc.format.mimetype application/pdf
- dc.identifier.citation Beato M, Sharma P. Peptidyl arginine deiminase 2 (PADI2)-mediated arginine citrullination modulates transcription in cancer. Int J Mol Sci. 2020 Feb 17; 21(4). pii: E1351. DOI: 10.3390/ijms21041351
- dc.identifier.doi http://dx.doi.org/10.3390/ijms21041351
- dc.identifier.issn 1422-0067
- dc.identifier.uri http://hdl.handle.net/10230/44226
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof International Journal of Molecular Sciences. 2020 Feb 17; 21(4). pii: E1351
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016–75006
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/609989
- dc.rights © 2020 by Miguel Beato and Priyanka Sharma. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.other Càncer
- dc.subject.other Arginina
- dc.subject.other Cèl·lules -- Proliferació
- dc.subject.other Quinases
- dc.title Peptidyl arginine deiminase 2 (PADI2)-mediated arginine citrullination modulates transcription in cancer
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion