A genome-wide association study of total child psychiatric problems scores
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- dc.contributor.author Neumann, Alexander
- dc.contributor.author Vilor Tejedor, Natàlia, 1988-
- dc.contributor.author Alemany, Silvia
- dc.contributor.author Sunyer Deu, Jordi
- dc.contributor.author Tiemeier, Henning
- dc.date.accessioned 2022-11-07T07:30:47Z
- dc.date.available 2022-11-07T07:30:47Z
- dc.date.issued 2022
- dc.description.abstract Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total score were shared with common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29). The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between related traits.
- dc.description.sponsorship The work of H. Tiemeier is further supported by a European Union’s Horizon 2020 research and innovation program (Contract grant number: 633595, DynaHealth) and a NWO-VICI grant (NWO-ZonMW: 016.VICI.170.200). https://www.nwo.nl/ The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- dc.format.mimetype application/pdf
- dc.identifier.citation Neumann A, Nolte IM, Pappa I, Ahluwalia TS, Pettersson E, Rodriguez A et al. A genome-wide association study of total child psychiatric problems scores. PLoS One. 2022 Aug 22;17(8):e0273116. DOI: 10.1371/journal.pone.0273116
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0273116
- dc.identifier.issn 1932-6203
- dc.identifier.uri http://hdl.handle.net/10230/54722
- dc.language.iso eng
- dc.publisher Public Library of Science (PLoS)
- dc.relation.ispartof PLoS One. 2022 Aug 22;17(8):e0273116
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633595
- dc.rights © 2022 Neumann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Human genetics
- dc.subject.keyword Genome-wide association studies
- dc.subject.keyword Clinical genetics
- dc.subject.keyword Single nucleotide polymorphisms
- dc.subject.keyword Gene expression
- dc.subject.keyword ADHD
- dc.subject.keyword Metaanalysis
- dc.subject.keyword Genetic loci
- dc.title A genome-wide association study of total child psychiatric problems scores
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion