Detailed assessment of night shift work aspects and potential mediators of its health effects: the contribution of field studies

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• dc.contributor.author van der Grinten, Tara
• dc.contributor.author van de Langenberg, Daniella
• dc.contributor.author van Kerkhof, Linda
• dc.contributor.author Harding, Barbara N.
• dc.contributor.author Garde, Anne Helene
• dc.contributor.author Laurell, Caisa
• dc.contributor.author Vermeulen, Roel
• dc.contributor.author Peters, Susan
• dc.contributor.author Vlaanderen, Jelle
• dc.date.accessioned 2025-07-31T07:19:46Z
• dc.date.available 2025-07-31T07:19:46Z
• dc.date.issued 2025
• dc.description.abstract Night shift work has been associated with adverse health outcomes, but inconsistencies in epidemiological findings reveal gaps in understanding the mechanisms involved. Beyond shift schedules (e.g., duration and intensity) and nighttime light exposure, we propose assessing ten key aspects to enhance understanding of shift work's nature and health implications. These include: (1) exposure-related factors ("meal timing and composition during the night shift," "physical activity during the night shift"); (2) potential mediators ("supplements and medication use," "social disruption," "sunlight exposure," "meal timing and dietary patterns outside shifts," "physical activity," "sleep quality," and "substance use"); and (3) effect modifiers ("occupational co-exposures"). Recent advances in technology, such as mobile apps, wearable sensors, and biomarkers, enable real-time, multidimensional assessments of these factors in field studies. Incorporating these tools into high-quality data collection can provide critical insights into the pathways linking night shift work and health. Such approaches will generate new hypotheses and inform the design of next-generation cohort and case-control studies, fostering a deeper understanding of this complex exposure and its health implications.
• dc.description.sponsorship The author(s) declare that financial support was received for the research and/or publication of this article. This work was conducted in the scope of the EPHOR project, funded by the European Union’s Horizon 2020 research and innovation program under grant agreement No. 874703. JV and RV were supported by the European Union’s Horizon 2020 research and innovation program under grant agreement No. 874627 (EXPANSE). AHG is supported by a grant from the Working Environment Research Fund in Denmark. BH was supported by grant IHMC22/00017 funded by the Instituto de Salud Carlos III (ISCIII) and by the “European Union Next Generation EU/PRTR.”
• dc.format.mimetype application/pdf
• dc.identifier.citation van der Grinten T, van de Langenberg D, van Kerkhof L, Harding BN, Garde AH, Laurell C, et al. Detailed assessment of night shift work aspects and potential mediators of its health effects: the contribution of field studies. Front Public Health. 2025 May 22;13:1578128. DOI: 10.3389/fpubh.2025.1578128
• dc.identifier.doi http://dx.doi.org/10.3389/fpubh.2025.1578128
• dc.identifier.issn 2296-2565
• dc.identifier.uri http://hdl.handle.net/10230/71043
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Front Public Health. 2025 May 22;13:1578128
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874703
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874627
• dc.rights © 2025 van der Grinten, van de Langenberg, van Kerkhof, Harding, Garde, Laurell, Vermeulen, Peters and Vlaanderen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. http://creativecommons.org/licenses/by/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Circadian rhythm
• dc.subject.keyword Light exposure
• dc.subject.keyword Occupational health
• dc.subject.keyword Risk factors
• dc.subject.keyword Sleep
• dc.subject.keyword Work schedule tolerance
• dc.title Detailed assessment of night shift work aspects and potential mediators of its health effects: the contribution of field studies
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion