Epithelial to mesenchymal transition in tumor cells as consequence of phenotypic instability

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• dc.contributor.author García de Herreros, Antonio
• dc.date.accessioned 2023-12-12T06:37:25Z
• dc.date.available 2023-12-12T06:37:25Z
• dc.date.issued 2014
• dc.description.abstract During the last years many articles have reported epithelial-to-mesenchymal transitions (EMT) induced by a myriad of gene products either when added to the cell medium or when transfected. Molecularly the EMT is characterized by the up-regulation of transcriptional factors (EMT-TFs) repressing the epithelial gene E-cadherin, a protein essential for the maintenance of the epithelial phenotype. These EMT-TFs are subjected to a complex regulation involving binary self-stimulatory loops, allowing the possibility of the amplification of input signals. The capability of EMT-TFs to promote an EMT is controlled by E-cadherin that limits the transcription of mesenchymal genes. We discuss here the differences between normal and tumor epithelial cells; in the latter a partial inactivation of E-cadherin function enables extracellular signals to be amplified and induce an EMT. This tumor cell phenotypic instability is exacerbated in cell culture conditions. Therefore, it is likely that many of the gene products reported to control this transition act only in very specific cell tumor cell lines; thus, in cells with an unstable phenotype due to pre-existing alterations in E-cadherin safeguard mechanism.
• dc.description.sponsorship Work in Antonio García de Herreros laboratory is supported by la Fundación Científica de la Asociación Española contra el Cáncer, Ministerio de Ciencia y Tecnología (SAF2013-48849-C2-1-R), Fundació La Marató de TV3, Fundación Rodríguez-Pascual and ISCIII/FEDER (RD12/0036/0005).
• dc.format.mimetype application/pdf
• dc.identifier.citation Garcí­a A. Epithelial to mesenchymal transition in tumor cells as consequence of phenotypic instability. Front Cell Dev Biol. 2014 Dec 12;2:71. DOI: 10.3389/fcell.2014.00071
• dc.identifier.doi http://dx.doi.org/10.3389/fcell.2014.00071
• dc.identifier.issn 2296-634X
• dc.identifier.uri http://hdl.handle.net/10230/58500
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Frontiers in Cell and Developmental Biology. 2014 Dec 12;2:71
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-48849-C2-1-R
• dc.rights © 2014 García de Herreros. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword EMT
• dc.subject.keyword Snail1
• dc.subject.keyword E-cadherin
• dc.subject.keyword Self-amplification
• dc.subject.keyword Tumor instability
• dc.title Epithelial to mesenchymal transition in tumor cells as consequence of phenotypic instability
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion