chroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Font-Burgada, Joanca
- dc.contributor.author Reina García, Óscar, 1976-ca
- dc.contributor.author Rossell, Davidca
- dc.contributor.author Azorín Marín, Fernandoca
- dc.date.accessioned 2018-07-11T10:48:28Z
- dc.date.available 2018-07-11T10:48:28Z
- dc.date.issued 2014
- dc.description.abstract Development of tools to jointly visualize the genome and the epigenome remains a challenge. chroGPS is a computational approach that addresses this question. chroGPS uses multidimensional scaling techniques to represent similarity between epigenetic factors, or between genetic elements on the basis of their epigenetic state, in 2D/3D reference maps. We emphasize biological interpretability, statistical robustness, integration of genetic and epigenetic data from heterogeneous sources, and computational feasibility. Although chroGPS is a general methodology to create reference maps and study the epigenetic state of any class of genetic element or genomic region, we focus on two specific kinds of maps: chroGPS(factors), which visualizes functional similarities between epigenetic factors, and chroGPS(genes), which describes the epigenetic state of genes and integrates gene expression and other functional data. We use data from the modENCODE project on the genomic distribution of a large collection of epigenetic factors in Drosophila, a model system extensively used to study genome organization and function. Our results show that the maps allow straightforward visualization of relationships between factors and elements, capturing relevant information about their functional properties that helps to interpret epigenetic information in a functional context and derive testable hypotheses.
- dc.description.sponsorship The Spanish ‘Ministerio de Economia y Competitividad’ [CSD2006-49, BFU2009-07111 and BFU2012-30724] and the ‘Generalitat de Catalunya’ [SGR2009-1023].This work was carried out within the framework of the ‘Centre de Referència en Biotecnologia’ of the ‘Generalitat de Catalunya’. Funding for open access charge: Spanish ‘Ministerio de Economia y Competitividad’ [BFU2012-30724]
- dc.format.mimetype application/pdf
- dc.identifier.citation Font-Burgada J, Reina O, Rossell D, Azorín F. chroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome. Nucleic Acids Res. 2014 Feb;42(4):2126-37. DOI: 10.1093/nar/gkt1186
- dc.identifier.doi http://dx.doi.org/10.1093/nar/gkt1186
- dc.identifier.issn 0305-1048
- dc.identifier.uri http://hdl.handle.net/10230/35138
- dc.language.iso eng
- dc.publisher Oxford University Pressca
- dc.relation.ispartof Nucleic Acids Research. 2014 Feb;42(4):2126-37
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-07111
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-30724
- dc.rights © 2014. Joan Font-Burgada, Oscar Reina, David Rossell et al ... Published by Oxford University Press. This is an Open Access article distributed under the terms of a Creative Commons Attribution License
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
- dc.subject.other Cromatina -- Metabolisme
- dc.subject.other Epigènesi
- dc.subject.other Genòmica
- dc.title chroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenomeca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion