What do we know about inequalities in NAFLD distribution and outcomes? A scoping review

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• dc.contributor.author Talens, Mar
• dc.contributor.author Tumas, Natalia
• dc.contributor.author Lazarus, Jeffrey V.
• dc.contributor.author Benach, Joan
• dc.contributor.author Pericàs, Juan
• dc.date.accessioned 2022-05-25T05:35:27Z
• dc.date.available 2022-05-25T05:35:27Z
• dc.date.issued 2021
• dc.description.abstract With prevalence high and rising given the close relationship with obesity and diabetes mellitus, non-alcoholic fatty liver disease (NAFLD) is progressively becoming the most common chronic liver condition worldwide. However, little is known about the health inequalities in NAFLD distribution and outcomes. This review aims to analyze health inequalities in NAFLD distribution globally and to assess the health disparities in NAFLD-related outcomes. We conducted a scoping review of global health inequalities in NAFLD distribution and outcomes according to gender/sex, ethnicity/race, and socioeconomic position from PubMed's inception to May 2021. Ultimately, 20 articles were included in the review, most (75%) of them carried out in the United States. Males were found to have a higher NAFLD prevalence (three articles), while available evidence suggests that women have an overall higher burden of advanced liver disease and complications (four articles), whereas they are less likely to be liver-transplanted once cirrhosis develops (one article). In the US, the Hispanic population had the highest NAFLD prevalence and poorer outcomes (seven articles), whereas Whites had fewer complications than other ethnicities (two articles). Patients with low socioeconomic status had higher NAFLD prevalence (four articles) and a higher likelihood of progression and complications (five articles). In conclusion, globally there is a lack of studies analyzing NAFLD prevalence and outcomes according to various axes of inequality through joint intersectional appraisals, and most studies included in our review were based on the US population. Available evidence suggests that NAFLD distribution and outcomes show large inequalities by social group. Further research on this issue is warranted.
• dc.format.mimetype application/pdf
• dc.identifier.citation Talens M, Tumas N, Lazarus JV, Benach J, Pericàs JM. What do we know about inequalities in NAFLD distribution and outcomes? A scoping review. J Clin Med. 2021 Oct 28;10(21):5019. DOI: 10.3390/jcm10215019
• dc.identifier.doi http://dx.doi.org/10.3390/jcm10215019
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/53241
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof J Clin Med. 2021 Oct 28;10(21):5019
• dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Health inequalities
• dc.subject.keyword Non-alcoholic fatty liver disease
• dc.subject.keyword Social determinants of health
• dc.title What do we know about inequalities in NAFLD distribution and outcomes? A scoping review
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion