Mortality risk prediction dynamics after heart failure treatment optimization: repeat risk assessment using online risk calculators

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Codina, Pau
• dc.contributor.author Zamora, Elisabet
• dc.contributor.author Levy, Wayne C.
• dc.contributor.author Revuelta-López, Elena
• dc.contributor.author Borrellas, Andrea
• dc.contributor.author Spitaleri, Giosafat
• dc.contributor.author Cediel, German
• dc.contributor.author Ruiz-Cueto, María
• dc.contributor.author Cañedo, Elena
• dc.contributor.author Santiago-Vacas, Evelyn
• dc.contributor.author Domingo, Mar
• dc.contributor.author Buchaca, David
• dc.contributor.author Subirana Cachinero, Isaac
• dc.contributor.author Santesmases, Javier
• dc.contributor.author de la Espriella, Rafael
• dc.contributor.author Núñez, Julio
• dc.contributor.author Lupón, Josep
• dc.contributor.author Bayes-Genis, Antoni
• dc.date.accessioned 2022-11-02T07:26:02Z
• dc.date.available 2022-11-02T07:26:02Z
• dc.date.issued 2022
• dc.description.abstract Objectives: heart failure (HF) management has significantly improved over the past two decades, leading to better survival. This study aimed to assess changes in predicted mortality risk after 12 months of management in a multidisciplinary HF clinic. Materials and methods: out of 1,032 consecutive HF outpatients admitted from March-2012 to November-2018, 357 completed the 12-months follow-up and had N-terminal pro-B-type natriuretic peptide (NTproBNP), high sensitivity troponin T (hs-TnT), and interleukin-1 receptor-like-1 (known as ST2) measurements available both at baseline and follow-up. Three contemporary risk scores were used: MAGGIC-HF, Seattle HF Model (SHFM), and the Barcelona Bio-HF (BCN Bio-HF) calculator, which incorporates the three above mentioned biomarkers. The predicted risk of all-cause death at 1 and 3 years was calculated at baseline and re-evaluated after 12 months. Results: a significant decline in predicted 1-and 3-year mortality risk was observed at 12 months: MAGGIC ~16%, SHFM ~22% and BCN Bio-HF ~15%. In the HF with reduced ejection fraction (HFrEF) subgroup guideline-directed medical therapy led to a complete normalization of left ventricular ejection fraction (≥50%) in almost a third of the patients and to a partial normalization (41-49%) in 30% of them. Repeated risk assessment after 12 months with SHFM and BCN Bio-HF provided adequate discrimination for all-cause 3-year mortality (C-Index: MAGGIC-HF 0.762, SHFM 0.781 and BCN Bio-HF 0.791). Conclusion: mortality risk declines in patients with HF managed for 12 months in a multidisciplinary HF clinic. Repeating the mortality risk assessment after optimizing the HF treatment is recommended, particularly in the HFrEF subgroup.
• dc.format.mimetype application/pdf
• dc.identifier.citation Codina P, Zamora E, Levy WC, Revuelta-López E, Borrellas A, Spitaleri G, et al. Mortality risk prediction dynamics after heart failure treatment optimization: repeat risk assessment using online risk calculators. Front Cardiovasc Med. 2022 Apr 12; 9: 836451. DOI: 10.3389/fcvm.2022.836451.
• dc.identifier.doi http://dx.doi.org/10.3389/fcvm.2022.836451
• dc.identifier.issn 2297-055X
• dc.identifier.uri http://hdl.handle.net/10230/54642
• dc.language.iso eng
• dc.publisher Frontiers
• dc.rights Copyright © 2022 Codina, Zamora, Levy, Revuelta-López, Borrellas, Spitaleri, Cediel, Ruiz-Cueto, Cañedo, Santiago-Vacas, Domingo, Buchaca, Subirana, Santesmases, Espriella, Nuñez, Lupón and Bayes-Genis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) http://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Heart failure
• dc.subject.keyword Mortality
• dc.subject.keyword Prognosis
• dc.subject.keyword Risk models
• dc.subject.keyword Risk prediction
• dc.title Mortality risk prediction dynamics after heart failure treatment optimization: repeat risk assessment using online risk calculators
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion