Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice
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- dc.contributor.author Zimmer, Andreasca
- dc.contributor.author Valjent, Emmanuelca
- dc.contributor.author König, Monikaca
- dc.contributor.author Zimmer, Anne M.ca
- dc.contributor.author Robledo, Patricia, 1958-ca
- dc.contributor.author Hahn, Heidica
- dc.contributor.author Valverde Granados, Olgaca
- dc.contributor.author Maldonado, Rafael, 1961-ca
- dc.date.accessioned 2012-07-05T06:54:13Z
- dc.date.available 2012-07-05T06:54:13Z
- dc.date.issued 2001ca
- dc.description.abstract The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chronic opioid effects were normal. The lack of negative motivational effects of THC in the absence of dynorphin demonstrates that this endogenous opioid peptide mediates the dysphoric effects of marijuana.
- dc.description.sponsorship This work was supported by European Commission BIOM ED-2 Grant 98-2227 (R.M.), Fondo de Investigaciones Sanitaria Grant 99/0624 (R.M.), Dr. Esteve S. A. Laboratories (R.M.), Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 400), and the Land Nordrhein-Westfalen (Innovationsprogramm Forschung) (A.Z.)
- dc.format.mimetype application/pdfca
- dc.identifier.citation Zimmer A, Valjent E, Konig M, Zimmer AM, Robledo P, Hahn H et al. Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. J Neurosci. 2001;21(23):9499-505. DOI: 10.1523/jneurosci.21-23-09499.2001ca
- dc.identifier.doi http://dx.doi.org/10.1523/jneurosci.21-23-09499.2001
- dc.identifier.issn 0270-6474ca
- dc.identifier.uri http://hdl.handle.net/10230/16667
- dc.language.iso engca
- dc.publisher Society for Neuroscienceca
- dc.relation.ispartof Journal of Neuroscience. 2001;21(23):9499-505
- dc.rights © 2001, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/21/23/9499ca
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Cannabinoid
- dc.subject.keyword Opioid
- dc.subject.keyword Mice
- dc.subject.keyword Mutation
- dc.subject.keyword Withdrawal
- dc.subject.keyword Addiction
- dc.subject.keyword Place aversion
- dc.subject.other Cannabinoides -- Efectes fisiològics
- dc.subject.other Cannabinoides -- Receptors
- dc.title Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient miceca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersion