Gut microbiota dynamics and association with chronic kidney disease: A longitudinal study within the PREDIMED-Plus trial
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- dc.contributor.author Atzeni, Alessandro
- dc.contributor.author Díaz López, Andrés
- dc.contributor.author Hernández Cacho, Adrián
- dc.contributor.author Babio, Nancy
- dc.contributor.author García-Gavilán, Jesús Francisco
- dc.contributor.author Cornejo-Pareja, Isabel
- dc.contributor.author Belzer, Clara
- dc.contributor.author Fitó Colomer, Montserrat
- dc.contributor.author Tinahones Madueño, Francisco José
- dc.contributor.author Salas-Salvadó, Jordi
- dc.date.accessioned 2025-07-03T06:15:46Z
- dc.date.available 2025-07-03T06:15:46Z
- dc.date.issued 2024
- dc.description.abstract Aims: Chronic kidney disease (CKD) represents a global health concern, disproportionately affecting the elderly with heightened cardiovascular risk. The emerging focus on the gut microbiota's role in CKD pathophysiology represents a pivotal area in nephrology; however, the evidence on this topic is limited. This observational prospective study, in the framework of the PREDIMED-Plus trial, investigates associations between gut microbiota composition and the 1-year trajectory of CKD in 343 participants aged 55-75 years with high cardiovascular risk. Materials and methods: Kidney function was assessed at baseline and at 1-year of follow-up through the estimated glomerular filtration rate based on cystatin C (eGFR-CysC) and CKD defined by eGFR-CysC <60 mL/min/1.73 m2. Participants were grouped based on their 1-year CKD trajectory: Group 1 maintained normal status or improved from CKD to normal, while Group 2 maintained CKD or worsened from normal to CKD. Fecal microbiota composition was assessed through 16S sequencing. Key findings: We observed differences in gut microbiota composition between CKD trajectory groups. Notably, the baseline relative abundance of Lachnoclostridium and Lachnospira, both butyrate-producing genera, was lower in participants maintaining or progressing to CKD. Longitudinally, a decrease in Lachnospira abundance was associated with CKD progression. The improved Chao1 index after 1-year follow-up suggests a link between enhanced microbial richness and stable/better kidney function. Significance: The findings underscore the potential of gut microbiota analysis in non-invasively monitoring CKD, especially in older populations, and hint at future interventions targeting gut microbiota to manage CKD progression. Further research is needed for causal relationships and generalizability.
- dc.format.mimetype application/pdf
- dc.identifier.citation Atzeni A, Díaz-López A, Cacho AH, Babio N, García-Gavilán JF, Cornejo-Pareja I, et al. Gut microbiota dynamics and association with chronic kidney disease: A longitudinal study within the PREDIMED-Plus trial. Life Sci. 2024 Aug 15;351:122863. DOI: 10.1016/j.lfs.2024.122863
- dc.identifier.doi http://dx.doi.org/10.1016/j.lfs.2024.122863
- dc.identifier.issn 0024-3205
- dc.identifier.uri http://hdl.handle.net/10230/70821
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Life Sci. 2024 Aug 15;351:122863
- dc.rights © 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Chronic kidney disease
- dc.subject.keyword Cystatin C
- dc.subject.keyword Gut microbiota
- dc.subject.keyword eGFR
- dc.title Gut microbiota dynamics and association with chronic kidney disease: A longitudinal study within the PREDIMED-Plus trial
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion