High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement

Montero, Maria Milagro; Mir Fontana, M. Luisa; Sulleiro, Elena; Avalos Esquivel, J.L.; García López, E.; Molina-Morant, D.; López Montesinos, Inmaculada; Sorli Redó, M. Luisa; Veliz Espinosa, G.; Mounteis Oliva, E.; Crespo Barrio, Marta; Monge, I.; Horcajada Gallego, Juan Pablo; Grau Cerrato, Santiago; Pascual Santos, Julio

doi:http://dx.doi.org/10.1016/j.ijid.2018.10.014

High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement

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Montero M, Mir M, Sulleiro E, Avalos Esquivel JL, García López E, Molina-Morant D et al. High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement. Int J Infect Dis. 2019 Jan;78:103-6. DOI: 10.1016/j.ijid.2018.10.014

Abstract

There is little published data on benznidazole dosing, or levels in cerebrospinal fluid. In this report, we describe the clinical course of an immunosuppressed patient with Chagas central nervous system involvement. He was treated successfully with larger benznidazole doses than are recommended, in order to reach therapeutically effective concentrations in the brain.