Sensation of electric fields in the Drosophila melanogaster larva
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- dc.contributor.author Tadres, David
- dc.contributor.author Riedl, Julia, 1981-
- dc.contributor.author Eden, Alexander
- dc.contributor.author Bontempo, Angela E.
- dc.contributor.author Lin, Jingtong
- dc.contributor.author Reid, Samuel F.
- dc.contributor.author Roehrich, Brian
- dc.contributor.author Williams, Kevin
- dc.contributor.author Sepunaru, Lior
- dc.contributor.author Louis, Matthieu
- dc.date.accessioned 2025-09-02T06:32:01Z
- dc.date.available 2025-09-02T06:32:01Z
- dc.date.issued 2025
- dc.description.abstract Electrosensation has emerged as a crucial sensory modality for social communication, foraging, and predation across the animal kingdom. However, its presence and functional role as well as the neural basis of electric field perception in Drosophila and other invertebrates remain unclear. In environments with controlled electric fields, we identified electrosensation as a new sense in the Drosophila melanogaster larva. We found that the Drosophila larva performs robust electrotaxis: when exposed to a uniform electric field, larvae migrate toward the cathode (negatively charged elecrode) and quickly respond to changes in the orientation of the field to maintain cathodal movement. Through a behavioral screen, we identified a subset of sensory neurons located at the tip of the larval head that are necessary for electrotaxis. Calcium imaging revealed that a pair of Gr66a-positive sensory neurons (one on each side of the head) encodes the strength and orientation of the electric field. Our results indicate that electric fields elicit robust behavioral and neural responses in the Drosophila larva, providing new evidence for the significance of electrosensation in invertebrates.
- dc.description.sponsorship This work was funded by the University of California, Santa Barbara (startup funds), the Spanish Ministry of Science and Innovation (MICINN, BFU2008-00362, BFU2009-07757-E/BMC, and BFU2011-26208), the “Centro de Excelencia Severo Ochoa 2013–2017,” the CERCA Programme/Generalitat de Catalunya, and the EMBL/CRG Systems Biology Program. K.W.’s work is supported by the National Institutes of Health (3R01NS054814).
- dc.format.mimetype application/pdf
- dc.identifier.citation Tadres D, Riedl J, Eden A, Bontempo AE, Lin J, Reid SF, et al. Sensation of electric fields in the Drosophila melanogaster larva. Curr Biol. 2025 Apr 21;35(8):1848-60.e4. DOI: 10.1016/j.cub.2025.03.014
- dc.identifier.doi http://dx.doi.org/10.1016/j.cub.2025.03.014
- dc.identifier.issn 0960-9822
- dc.identifier.uri http://hdl.handle.net/10230/71093
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Curr Biol. 2025 Apr 21;35(8):1848-60.e4
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2008-00362
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-07757
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-26208
- dc.rights © 2025 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Drosophila larva
- dc.subject.keyword Gr33a
- dc.subject.keyword Gr66a
- dc.subject.keyword Electrosensation
- dc.subject.keyword Electrotaxis
- dc.subject.keyword Galvanotaxis
- dc.subject.keyword Gustatory neurons
- dc.subject.keyword Sensory navigation
- dc.subject.keyword Sensory neuroscience
- dc.title Sensation of electric fields in the Drosophila melanogaster larva
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion