Dynamics of microRNA expression during mouse prenatal development

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  • dc.contributor.author Rahmanian, Sorena
  • dc.contributor.author Guigó Serra, Roderic
  • dc.contributor.author Mortazavi, Ali
  • dc.date.accessioned 2019-12-13T08:33:04Z
  • dc.date.issued 2019
  • dc.description.abstract MicroRNAs (miRNAs) play a critical role as posttranscriptional regulators of gene expression. The ENCODE Project profiled the expression of miRNAs in an extensive set of organs during a time-course of mouse embryonic development and captured the expression dynamics of 785 miRNAs. We found distinct organ-specific and developmental stage-specific miRNA expression clusters, with an overall pattern of increasing organ-specific expression as embryonic development proceeds. Comparative analysis of conserved miRNAs in mouse and human revealed stronger clustering of expression patterns by organ type rather than by species. An analysis of messenger RNA expression clusters compared with miRNA expression clusters identifies the potential role of specific miRNA expression clusters in suppressing the expression of mRNAs specific to other developmental programs in the organ in which these miRNAs are expressed during embryonic development. Our results provide the most comprehensive time-course of miRNA expression as part of an integrated ENCODE reference data set for mouse embryonic development.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Rahmanian S, Murad R, Breschi A, Zeng W, Mackiewicz M, Williams B et al. Dynamics of microRNA expression during mouse prenatal development. Genome Res. 2019;29(11):1900-9. DOI: 10.1101/gr.248997.119
  • dc.identifier.doi http://dx.doi.org/10.1101/gr.248997.119
  • dc.identifier.issn 1088-9051
  • dc.identifier.uri http://hdl.handle.net/10230/43159
  • dc.language.iso eng
  • dc.publisher Cold Spring Harbor Laboratory Press (CSHL Press)
  • dc.relation.ispartof Genome Research. 2019;29(11):1900-9
  • dc.rights © 2019 Rahmanian et al.; Published by Cold Spring Harbor Laboratory Press. This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.title Dynamics of microRNA expression during mouse prenatal development
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Center for Genomic Regulation (CRG))
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