Signaling by steroid hormones in the 3D nuclear space
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- dc.contributor.author Le Dily, François
- dc.contributor.author Beato, Miguel
- dc.date.accessioned 2019-11-20T08:48:50Z
- dc.date.available 2019-11-20T08:48:50Z
- dc.date.issued 2018
- dc.description.abstract Initial studies showed that ligand-activated hormone receptors act by binding to the proximal promoters of individual target genes. Genome-wide studies have now revealed that regulation of transcription by steroid hormones mainly depends on binding of the receptors to distal regulatory elements. Those distal elements, either enhancers or silencers, act on the regulation of target genes by chromatin looping to the gene promoters. In the nucleus, this level of chromatin folding is integrated within dynamic higher orders of genome structures, which are organized in a non-random fashion. Terminally differentiated cells exhibit a tissue-specific three-dimensional (3D) organization of the genome that favors or restrains the activity of transcription factors and modulates the function of steroid hormone receptors, which are transiently activated upon hormone exposure. Conversely, integration of the hormones signal may require modifications of the 3D organization to allow appropriate transcriptional outcomes. In this review, we summarize the main levels of organization of the genome, review how they can modulate the response to steroids in a cell specific manner and discuss the role of receptors in shaping and rewiring the structure in response to hormone. Taking into account the dynamics of 3D genome organization will contribute to a better understanding of the pleiotropic effects of steroid hormones in normal and cancer cells.
- dc.description.sponsorship We thank all members of the Chromatin and Gene Expression group (CRG, Barcelona) and the members of the 4DGenome project (CRG and CNAG-CRG, Barcelona) for helpful discussions. Research in the Beato’s laboratory receives funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC Synergy grant agreement 609989 (4DGenome). The content of this manuscript reflects only the author’s views and the Union is not liable for any use that may be made of the information contained therein. We also acknowledge support of the Spanish Ministry of Economy and Competitiveness, “Centro de Excelencia Severo Ochoa 2013-2017” and Plan Nacional (SAF2016-75006-P), as well as support of the CERCA Programme/Generalitat de Catalunya.
- dc.format.mimetype application/pdf
- dc.identifier.citation Le Dily F, Beato M. Signaling by steroid hormones in the 3D nuclear space. Int J Mol Sci. 2018;19(2):306. DOI: 10.3390/ijms19020306
- dc.identifier.doi http://dx.doi.org/10.3390/ijms19020306
- dc.identifier.issn 1422-0067
- dc.identifier.uri http://hdl.handle.net/10230/42909
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof International Journal of Molecular Sciences. 2018;19(2):306
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/609989
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-75006-P
- dc.rights © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Chromatin conformation
- dc.subject.keyword Estrogen receptor
- dc.subject.keyword Steroid receptors
- dc.subject.keyword Topological domains
- dc.subject.keyword Transcription regulation
- dc.title Signaling by steroid hormones in the 3D nuclear space
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion