Molecular characterisation of triple negative essential thrombocythaemia patients by platelet analysis and targeted sequencing.
Molecular characterisation of triple negative essential thrombocythaemia patients by platelet analysis and targeted sequencing.
Citació
- Angona A, Fernández-Rodríguez C, Alvarez-Larrán A, Camacho L, Longarón R, Torres E. et al. Molecular characterisation of triple negative essential thrombocythaemia patients by platelet analysis and targeted sequencing. Blood Cancer J. 2016 Aug 26;6(8):e463. DOI: 10.1038/bcj.2016.75
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Descripció
Resum
Essential thrombocythaemia (ET) is a myeloproliferative neoplasm(MPN) characterised by megakaryocyte hyperplasia and thrombo-cytosis. From the genetic perspective, ET patients harbourmutations inJAK2(50–60%),CALR(15–30%) andMPL(1–5%) genes.