Reactive oxygen species activate the Drosophila TNF receptor Wengen for damage-induced regeneration

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• dc.contributor.author Esteban-Collado, José
• dc.contributor.author Fernández Mañas, Mar
• dc.contributor.author Fernández-Moreno, Manuel
• dc.contributor.author Maeso, Ignacio
• dc.contributor.author Corominas Guiu, Montserrat
• dc.contributor.author Serras Rigalt, Florenci
• dc.date.accessioned 2024-12-02T16:18:57Z
• dc.date.available 2024-12-02T16:18:57Z
• dc.date.issued 2024
• dc.description.abstract Tumor necrosis factor receptors (TNFRs) control pleiotropic pro-inflammatory functions that range from apoptosis to cell survival. The ability to trigger a particular function will depend on the upstream cues, association with regulatory complexes, and downstream pathways. In Drosophila melanogaster, two TNFRs have been identified, Wengen (Wgn) and Grindelwald (Grnd). Although several reports associate these receptors with JNK-dependent apoptosis, it has recently been found that Wgn activates a variety of other functions. We demonstrate that Wgn is required for survival by protecting cells from apoptosis. This is mediated by dTRAF1 and results in the activation of p38 MAP kinase. Remarkably, Wgn is required for apoptosis-induced regeneration and is activated by the reactive oxygen species (ROS) produced following apoptosis. This ROS activation is exclusive for Wgn, but not for Grnd, and can occur after knocking down Eiger/TNFα. The extracellular cysteine-rich domain of Grnd is much more divergent than that of Wgn, which is more similar to TNFRs from other animals, including humans. Our results show a novel TNFR function that responds to stressors by ensuring p38-dependent regeneration.
• dc.description.sponsorship The authors would like to thank Dr. Manel Bosch from the Optical Microscopy Unit of the CCiT od the Universitat de Barcelona for his assistance. We also thank Marco Milán and Lidia Pérez for sharing the wild-type form of licorne (UAS-licWT1.1). We also thank Paula Santa Bárbara Ruiz for her preliminary observations. This research was funded by the Spanish Ministerio de Ciencia, Innovación y Universidades (PID2021-123300NB-100) and by the Agència de Gestió d’Ajuts Universitaris i de Recerca of the Generalitat de Catalunya (2021SGR00293) to FS, MC, and JEC, and by Spanish Ministerio de Ciencia, Innovación y Universidades(PID2021-128728NB-I00 and CNS2022-136105) to NM and MFM.
• dc.format.mimetype application/pdf
• dc.identifier.citation Esteban-Collado J, Fernández-Mañas M, Fernández-Moreno M, Maeso I, Corominas M, Serras F. Reactive oxygen species activate the Drosophila TNF receptor Wengen for damage-induced regeneration. EMBO J. 2024 Sep;43(17):3604-26. DOI: 10.1038/s44318-024-00155-9
• dc.identifier.doi http://dx.doi.org/10.1038/s44318-024-00155-9
• dc.identifier.issn 0261-4189
• dc.identifier.uri http://hdl.handle.net/10230/68881
• dc.language.iso eng
• dc.publisher EMBO Press
• dc.relation.ispartof EMBO J. 2024 Sep;43(17):3604-26
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2021-123300NB-100
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2021-128728NB-I00
• dc.rights © 2024 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Apoptosis
• dc.subject.keyword Cell signaling
• dc.subject.keyword Cytokines
• dc.subject.keyword Oxidative stress
• dc.subject.keyword Regeneration
• dc.title Reactive oxygen species activate the Drosophila TNF receptor Wengen for damage-induced regeneration
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion