Role of HDL function and LDL atherogenicity on cardiovascular risk: a comprehensive examination

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  • dc.contributor.author Hernáez, Álvaro
  • dc.contributor.author Soria-Florido, Maria
  • dc.contributor.author Schröder, Helmut, 1958-
  • dc.contributor.author Ros, Emilio
  • dc.contributor.author Pinto, Xavier
  • dc.contributor.author Estruch, Ramón
  • dc.contributor.author Salas-Salvadó, Jordi
  • dc.contributor.author Corella, Dolores
  • dc.contributor.author Arós, Fernando
  • dc.contributor.author Serra-Majem, Luis
  • dc.contributor.author Martínez-González, Miguel Ángel, 1957-
  • dc.contributor.author Fiol, Miquel
  • dc.contributor.author Lapetra, José
  • dc.contributor.author Elosua Llanos, Roberto
  • dc.contributor.author Lamuela-Raventós, Rosa M.
  • dc.contributor.author Fitó Colomer, Montserrat
  • dc.date.accessioned 2020-03-27T07:22:24Z
  • dc.date.available 2020-03-27T07:22:24Z
  • dc.date.issued 2019
  • dc.description.abstract Background: High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol levels. However, it is unclear how these lipoprotein properties are particularly affected by different cardiovascular risk factors. Objective: To determine which lipoprotein properties are associated with greater cardiovascular risk scores and each cardiovascular risk factor. Methods: In two cross-sectional baseline samples of PREDIMED trial volunteers, we assessed the associations of HDL functionality (N = 296) and LDL atherogenicity traits (N = 210) with: 1) the 10-year predicted coronary risk (according to the Framingham-REGICOR score), and 2) classical cardiovascular risk factors. Results: Greater cardiovascular risk scores were associated with low cholesterol efflux values; oxidized, triglyceride-rich, small HDL particles; and small LDLs with low resistance against oxidation (P-trend<0.05, all). After adjusting for the rest of risk factors; 1) type-2 diabetic individuals presented smaller and more oxidized LDLs (P<0.026, all); 2) dyslipidemic participants had smaller HDLs with an impaired capacity to metabolize cholesterol (P<0.035, all); 3) high body mass index values were associated to lower HDL and LDL size and a lower HDL capacity to esterify cholesterol (P<0.037, all); 4) men presented a greater HDL oxidation and lower HDL vasodilatory capacity (P<0.046, all); and 5) greater ages were related to small, oxidized, cytotoxic LDL particles (P<0.037, all). Conclusions: Dysfunctional HDL and atherogenic LDL particles are present in high cardiovascular risk patients. Dyslipidemia and male sex are predominantly linked to HDL dysfunctionality, whilst diabetes and advanced age are associated with LDL atherogenicity.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Hernáez Á, Soria-Florido MT, Schröder H, Ros E, Pintó X, Estruch R, et al. Role of HDL function and LDL atherogenicity on cardiovascular risk: a comprehensive examination. PLoS One. 2019 Jun 27; 14(6):e0218533. DOI: 10.1371/journal.pone.0218533
  • dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0218533
  • dc.identifier.issn 1932-6203
  • dc.identifier.uri http://hdl.handle.net/10230/44057
  • dc.language.iso eng
  • dc.publisher Public Library of Science (PLoS)
  • dc.rights © 2019 Hernáez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License,https://creativecommons.org/licenses/by/4.0/ which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Lipoproteïnes
  • dc.subject.other Colesterol
  • dc.subject.other Sistema cardiovascular--Malalties
  • dc.title Role of HDL function and LDL atherogenicity on cardiovascular risk: a comprehensive examination
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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