The clinical impact of using complex molecular profiling strategies in routine oncology practice
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- dc.contributor.author Laes, Jean-François
- dc.contributor.author Aftimos, Philippe
- dc.contributor.author Bellmunt Molins, Joaquim, 1959-
- dc.contributor.author Sadik, Helen
- dc.date.accessioned 2019-07-04T06:26:25Z
- dc.date.available 2019-07-04T06:26:25Z
- dc.date.issued 2018
- dc.description.abstract Molecular profiling and functional assessment of signalling pathways of advanced solid tumours are becoming increasingly available. However, their clinical utility in guiding patients' treatment remains unknown. Here, we assessed whether molecular profiling helps physicians in therapeutic decision making by analysing the molecular profiles of 1057 advanced cancer patient samples after failing at least one standard of care treatment using a combination of next-generation sequencing (NGS), immunohistochemistry (IHC) and other specific tests. The resulting information was interpreted and personalized treatments for each patient were suggested. Our data showed that NGS alone provided the oncologist with useful information in 10-50% of cases (depending on cancer type), whereas the addition of IHC/other tests increased extensively the usefulness of the information provided. Using internet surveys, we investigated how therapy recommendations influenced treatment choice of the oncologist. For patients who were still alive after the provision of the molecular information (76.8%), 60.4% of their oncologists followed report recommendations. Most treatment decisions (93.4%) were made based on the combination of NGS and IHC/other tests, and an approved drug- rather than clinical trial enrolment- was the main treatment choice. Most common reasons given by physicians to explain the non-adherence to recommendations were drug availability and cost, which remain barriers to personalised precision medicine. Finally, we observed that 27% of patients treated with the suggested therapies had an overall survival > 12 months. Our study demonstrates that the combination of NGS and IHC/other tests provides the most useful information in aiding treatment decisions by oncologists in routine clinical practice.
- dc.format.mimetype application/pdf
- dc.identifier.citation Laes JF, Aftimos P, Barthelemy P, Bellmunt J, Berchem G, Camps C. et al. The clinical impact of using complex molecular profiling strategies in routine oncology practice. Oncotarget. 2018 Apr 17;9(29):20282-20293. DOI: 10.18632/oncotarget.24757
- dc.identifier.doi http://dx.doi.org/10.18632/oncotarget.24757
- dc.identifier.issn 1949-2553
- dc.identifier.uri http://hdl.handle.net/10230/41925
- dc.language.iso eng
- dc.publisher Impact Journal
- dc.rights Copyright : © 2018 Laes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/3.0/
- dc.subject.keyword Molecular profiling
- dc.subject.keyword Next-generation sequencing
- dc.subject.keyword Precision medicine
- dc.subject.keyword Solid tumour
- dc.subject.keyword Therapeutic decision making in oncology
- dc.title The clinical impact of using complex molecular profiling strategies in routine oncology practice
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion