Mapping the neural systems driving breathing at the transition to unconsciousness
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- dc.contributor.author Pujol Martí, Jesús, 1981-
- dc.contributor.author Blanco Hinojo, Laura, 1981-
- dc.contributor.author Ortiz, Héctor
- dc.contributor.author Gallart Gallego, Lluís
- dc.contributor.author Moltó, Luis
- dc.contributor.author Martínez-Vilavella, Gerard
- dc.contributor.author Vilà, Esther
- dc.contributor.author Pacreu, Susana
- dc.contributor.author Adalid, Irina
- dc.contributor.author Deus, Joan
- dc.contributor.author Pérez Solá, Victor
- dc.contributor.author Fernández-Candil, Juan-Luis
- dc.date.accessioned 2022-09-19T06:52:11Z
- dc.date.available 2022-09-19T06:52:11Z
- dc.date.issued 2022
- dc.description.abstract After falling asleep, the brain needs to detach from waking activity and reorganize into a functionally distinct state. A functional MRI (fMRI) study has recently revealed that the transition to unconsciousness induced by propofol involves a global decline of brain activity followed by a transient reduction in cortico-subcortical coupling. We have analyzed the relationships between transitional brain activity and breathing changes as one example of a vital function that needs the brain to readapt. Thirty healthy participants were originally examined. The analysis involved the correlation between breathing and fMRI signal upon loss of consciousness. We proposed that a decrease in ventilation would be coupled to the initial decline in fMRI signal in brain areas relevant for modulating breathing in the awake state, and that the subsequent recovery would be coupled to fMRI signal in structures relevant for controlling breathing during the unconscious state. Results showed that a slight reduction in breathing from wakefulness to unconsciousness was distinctively associated with decreased activity in brain systems underlying different aspects of consciousness including the prefrontal cortex, the default mode network and somatosensory areas. Breathing recovery was distinctively coupled to activity in deep brain structures controlling basic behaviors such as the hypothalamus and amygdala. Activity in the brainstem, cerebellum and hippocampus was associated with breathing variations in both states. Therefore, our brain maps illustrate potential drives to breathe, unique to wakefulness, in the form of brain systems underlying cognitive awareness, self-awareness and sensory awareness, and to unconsciousness involving structures controlling instinctive and homeostatic behaviors.
- dc.format.mimetype application/pdf
- dc.identifier.citation Pujol J, Blanco-Hinojo L, Ortiz H, Gallart L, Moltó L, Martínez-Vilavella G, et al. Mapping the neural systems driving breathing at the transition to unconsciousness. Neuroimage. 2022 Feb 1; 246: 118779. DOI: 10.1016/j.neuroimage.2021.11877
- dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2021.11877
- dc.identifier.issn 1053-8119
- dc.identifier.uri http://hdl.handle.net/10230/54103
- dc.language.iso eng
- dc.publisher Elsevier
- dc.rights 1053-8119/© 2021 Pujol J, Blanco-Hinojo L, Ortiz H, Gallart L, Moltó L, Martínez-Vilavella G. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Consciousness
- dc.subject.keyword Functional MRI
- dc.subject.keyword Respiration
- dc.subject.keyword Sleep
- dc.subject.keyword Wakefulness
- dc.subject.keyword Neural systems
- dc.title Mapping the neural systems driving breathing at the transition to unconsciousness
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion