Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

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• dc.contributor.author Nowak, Katarzyna
• dc.contributor.author Seisenbacher, Gerhard
• dc.contributor.author Hafen, Ernst
• dc.contributor.author Stocker, Hugo
• dc.date.accessioned 2024-05-21T06:17:12Z
• dc.date.available 2024-05-21T06:17:12Z
• dc.date.issued 2013
• dc.description.abstract How single cells in a mitotic tissue progressively acquire hallmarks of cancer is poorly understood. We exploited mitotic recombination in developing Drosophila imaginal tissues to analyze the behavior of cells devoid of the tumor suppressor PTEN, a negative regulator of PI3K signaling, under varying nutritional conditions. Cells lacking PTEN strongly overproliferated specifically in nutrient restricted larvae. Although the PTEN mutant cells were sensitive to starvation, they successfully competed with neighboring cells by autonomous and non-autonomous mechanisms distinct from cell competition. The overgrowth was strictly dependent on the activity of the downstream components Akt/PKB and TORC1, and a reduction in amino acid uptake by reducing the levels of the amino acid transporter Slimfast caused clones of PTEN mutant cells to collapse. Our findings demonstrate how limiting nutritional conditions impact on cells lacking the tumor suppressor PTEN to cause hyperplastic overgrowth.
• dc.format.mimetype application/pdf
• dc.identifier.citation Nowak K, Seisenbacher G, Hafen E, Stocker H. Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues. eLife. 2013 Jul 9;2:e00380. DOI: 10.7554/eLife.00380
• dc.identifier.doi http://dx.doi.org/10.7554/eLife.00380
• dc.identifier.issn 2050-084X
• dc.identifier.uri http://hdl.handle.net/10230/60187
• dc.language.iso eng
• dc.publisher eLife
• dc.relation.ispartof eLife. 2013 Jul 9;2:e00380
• dc.rights © 2013, Nowak et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/3.0/
• dc.subject.other Marcadors tumorals
• dc.subject.other Càncer
• dc.subject.other Nutrició
• dc.title Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion