Association of exposure to mixture of chemicals during pregnancy with cognitive abilities and fine motor function of children

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• dc.contributor.author Brennan Kearns, Pavla
• dc.contributor.author van den Dries, Michiel
• dc.contributor.author Julvez, Jordi
• dc.contributor.author Kampouri, Mariza
• dc.contributor.author López Vicente, Mònica, 1988-
• dc.contributor.author Maitre, Léa
• dc.contributor.author Philippat, Claire
• dc.contributor.author Haug, Line Småstuen
• dc.contributor.author Vafeiadi, Marina, 1983-
• dc.contributor.author Thomsen, Cathrine
• dc.contributor.author Yang, Tiffany C.
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Tiemeier, Henning
• dc.contributor.author Guxens Junyent, Mònica
• dc.date.accessioned 2024-06-25T06:14:29Z
• dc.date.available 2024-06-25T06:14:29Z
• dc.date.issued 2024
• dc.description.abstract Chemical exposures often occur in mixtures and exposures during pregnancy may lead to adverse effects on the fetal brain, potentially reducing lower cognitive abilities and fine motor function of the child. We investigated the association of motheŕs exposure to a mixture of chemicals during pregnancy (i.e., organochlorine compounds, per- and polyfluoroalkyl substances, phenols, phthalates, organophosphate pesticides) with cognitive abilties and fine motor function in their children. We studied 1097 mother-child pairs from five European cohorts participating in the Human Early Life Exposome study (HELIX). Measurement of 26 biomarkers of exposure to chemicals was performed on urine or blood samples of pregnant women (mean age 31 years). Cognitive abilities and fine motor function were assessed in their children (mean age 8 years) with a battery of computerized tests administered in person (Raveńs Coloured Progressive Matrices, Attention Network Test, N-back Test, Trail Making Test, Finger Tapping Test). We estimated the joint effect of prenatal exposure to chemicals on cognitive abilities and fine motor function using the quantile-based g-computation method, adjusting for sociodemographic characteristics. A quartile increase in all the chemicals in the overall mixture was associated with worse fine motor function, specifically lower scores in the Finger Tapping Test [-8.5 points, 95 % confidence interval (CI) -13.6 to -3.4; -14.5 points, 95 % CI -22.4 to -6.6, and -18.0 points, 95 % CI -28.6 to -7.4) for the second, third and fourth quartile of the overal mixture, respectively, when compared to the first quartile]. Organochlorine compounds, phthalates, and per- and polyfluoroalkyl substances contributed most to this association. We did not find a relationship with cognitive abilities. We conclude that exposure to chemical mixtures during pregnancy may influence neurodevelopment, impacting fine motor function of the offspring.
• dc.description.sponsorship The study was supported by the European Community’s Seventh Framework Programme [FP7/2007–2013] under grant agreement no. 308333 [the HELIX project], and by the European Union’s Horizon 2020 research and innovation programme under grant agreements no. 874583 [ATHLETE], and no. 733032 [HBM4EU]. We further acknowledge funding from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds, CPII18/00018), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds, Juan de la Cierva-Incorporación fellowship IJC2018-035394-I), Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010), EU Commission (261357, 603794 and 634453), project IJC2020-045355-I, funded by MCIN/AEI/10.13039/501100011033 and by the European Union NextGenerationEU/PRTR. We also acknowledge support from the grant CEX2018-000806-S funded by MCIN/AEI/ 10.13039/501100011033, the European Union NextGenerationEU/PRTR and support from the Generalitat de Catalunya through the CERCA Program. BiB receives funding from by a joint grant from the UK Medical Research Council (MRC) and UK Economic and Social Science Research Council (ESRC) [MR/N024391/1]; the British Heart Foundation [CS/16/4/32482]; a Wellcome Infrastructure Grant [WT101597MA]; The National Institute for Health Research under its Applied Research Collaboration for Yorkshire and Humber [NIHR200166]. The views expressed are those of the author(s), and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The authors acknowledge that BiB is only possible because of the enthusiasm and commitment of the children and parents in BiB. We are grateful to all participants, health professionals and researchers who have made BiB happen. MoBa is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research. EDEN was supported by Foundation for medical research (FRM), National Agency for Research (ANR), National Institute for Research in Public health (IRESP: TGIR cohorte santé 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A), and Human Nutrition National Research Programs, Paris-Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients (AFD)), French Agency for Environmental Health Safety (now ANSES), Mutuelle Générale de l’Education Nationale a complementary health insurance (MGEN), French national agency for food security, French-speaking association for the study of diabetes and metabolism (ALFEDIAM). RHEA was supported by the General Secretariat for Research and Technology in Greece and the Research Committee of the University of Crete, Greece. We acknowledge the input of the entire HELIX consortium. We are grateful to all the participating families in the cohorts that took part in this study and all fieldworkers. The funding sources had no role in the conceptualization of this manuscript.
• dc.format.mimetype application/pdf
• dc.identifier.citation Brennan Kearns P, van den Dries MA, Julvez J, Kampouri M, López-Vicente M, Maitre L, et al. Association of exposure to mixture of chemicals during pregnancy with cognitive abilities and fine motor function of children. Environ Int. 2024 Mar;185:108490. DOI: 10.1016/j.envint.2024.108490
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2024.108490
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/60586
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Int. 2024 Mar;185:108490
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733032
• dc.rights © 2024 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Chemical mixtures
• dc.subject.keyword Cognitive abilities
• dc.subject.keyword Fine motor function
• dc.subject.keyword Neurodevelopment
• dc.subject.keyword Prenatal exposures
• dc.title Association of exposure to mixture of chemicals during pregnancy with cognitive abilities and fine motor function of children
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion