Association of iron status and intake during pregnancy with neuropsychological outcomes in children aged 7 years: the prospective birth cohort Infancia y Medio Ambiente (INMA) study

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Arija, Victoria
• dc.contributor.author Hernández-Martínez, Carmen
• dc.contributor.author Tous, Mónica
• dc.contributor.author Canals, Josefa
• dc.contributor.author Guxens Junyent, Mònica
• dc.contributor.author Fernández-Barrés, Sílvia
• dc.contributor.author Ibarluzea, Jesús
• dc.contributor.author Babarro, Izaro
• dc.contributor.author Soler Blasco, Raquel
• dc.contributor.author Llop, Sabrina
• dc.contributor.author Vioque, Jesus
• dc.contributor.author Sunyer Deu, Jordi
• dc.contributor.author Julvez, Jordi
• dc.date.accessioned 2020-01-10T08:39:00Z
• dc.date.available 2020-01-10T08:39:00Z
• dc.date.issued 2019
• dc.description.abstract Early iron status plays an important role in prenatal neurodevelopment. Iron deficiency and high iron status have been related to alterations in child cognitive development; however, there are no data about iron intake during pregnancy with other environmental factors in relation to long term cognitive functioning of children. The aim of this study is to assess the relationship between maternal iron status and iron intake during pregnancy and child neuropsychological outcomes at 7 years of age. We used data from the INMA Cohort population-based study. Iron status during pregnancy was assessed according to serum ferritin levels, and iron intake was assessed with food frequency questionnaires. Working memory, attention, and executive function were assessed in children at 7 years old with the N-Back task, Attention Network Task, and the Trail Making Test, respectively. The results show that, after controlling for potential confounders, normal maternal serum ferritin levels (from 12 mg/L to 60 mg/L) and iron intake (from 14.5 mg/day to 30.0 mg/day), respectively, were related to better scores in working memory and executive functioning in offspring. Since these functions have been associated with better academic performance and adaptation to the environment, maintaining a good state of maternal iron from the beginning of pregnancy could be a valuable strategy for the community.
• dc.description.sponsorship This study was funded by Instituto de Salud Carlos III through the projects ‘CP14/00108 & PI16/00261’ (co-funded by European Regional Development Fund ‘A way to make Europe’). J.J., M.G., and S.L. hold Miguel Servet contracts (MS14/00108, MS13/00054, and MS15/00025/00051, respectively) awarded by the Spanish Institute of Health Carlos III (Ministry of Economy and Competitiveness). This study was also funded by grants from Instituto de Salud Carlos III (Red INMA G03/176), Generalitat de Catalunya-CIRIT 1999SGR 00241. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. This study was additionally funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR 2009 SGR 501, Fundació La marató de TV3 (090430), EU Commission (261357). ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. This study was finally funded by Grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), Spain: ISCIII (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, and PI17/00663; Miguel Servet-FEDER CP11/00178, CP15/00025, and CPII16/00051), Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249), and Alicia Koplowitz Foundation 2017.
• dc.format.mimetype application/pdf
• dc.identifier.citation Arija V, Hernández-Martínez C, Tous M, Canals J, Guxens M, Fernández-Barrés S, Ibarluzea J, Babarro I, Soler-Blasco R, Llop S, Vioque J, Sunyer J, Julvez J. Association of iron status and intake during pregnancy with neuropsychological outcomes in children aged 7 years: the prospective birth cohort Infancia y Medio Ambiente (INMA) study. Nutrients. 2019; 11(12). pii: E2999. DOI 10.3390/nu11122999
• dc.identifier.doi http://dx.doi.org/10.3390/nu11122999
• dc.identifier.issn 2072-6643
• dc.identifier.uri http://hdl.handle.net/10230/43253
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Nutrients. 2019; 11(12). pii: E2999
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
• dc.rights © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Attention
• dc.subject.keyword Executive function
• dc.subject.keyword Iron intake
• dc.subject.keyword Iron status
• dc.subject.keyword Neuropsychological function
• dc.subject.keyword Pregnancy
• dc.subject.keyword Working memory
• dc.title Association of iron status and intake during pregnancy with neuropsychological outcomes in children aged 7 years: the prospective birth cohort Infancia y Medio Ambiente (INMA) study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion