Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial

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• dc.contributor.author Domínguez-López, Inés
• dc.contributor.author Lamuela-Raventós, Rosa M.
• dc.contributor.author Razquin, Cristina
• dc.contributor.author Arancibia-Riveros, Camila
• dc.contributor.author Galkina, Polina
• dc.contributor.author Salas Salvadó, Jordi
• dc.contributor.author Alonso-Gómez, Ángel
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Fiol, Miquel
• dc.contributor.author Lapetra, José
• dc.contributor.author Gómez-Gracia, Enrique
• dc.contributor.author Sorlí, José Vicente
• dc.contributor.author Ruiz-Canela, Miguel
• dc.contributor.author Castañer, Olga
• dc.contributor.author Liang, Liming
• dc.contributor.author Serra-Majem, Luis
• dc.contributor.author Hu, Frank B.
• dc.contributor.author Ros, Emilio
• dc.contributor.author Martínez-González, Miguel Ángel, 1957-
• dc.contributor.author Estruch, Ramón
• dc.date.accessioned 2025-11-12T14:26:22Z
• dc.date.available 2025-11-12T14:26:22Z
• dc.date.issued 2025
• dc.date.updated 2025-11-12T14:26:22Z
• dc.description.abstract Background and aims: Moderate wine consumption has been associated with lower cardiovascular disease (CVD) risk in older populations. However, wine consumption information through self-reports is prone to measurement errors inherent to subjective assessments. The aim of this study was to evaluate the association between urinary tartaric acid, an objective biomarker of wine consumption, and the rate of a composite clinical CVD event. Methods: A case-cohort nested study was designed within the PREDIMED trial with 1232 participants: 685 incident cases of CVD and a random subcohort of 625 participants (including 78 overlapping cases). Wine consumption was registered using validated food frequency questionnaires. Liquid chromatography-tandem mass spectrometry was used to measure urinary tartaric acid at baseline and after one year of intervention. Weighted Cox regression models were used to estimate hazard ratios (HRs) of CVD. Results: Tartaric acid was correlated with self-reported wine consumption at baseline [r = 0.46 (95% CI 0.41; 0.50)]. Five categories of post hoc urinary tartaric acid excretion were used for better representation of risk patterns. Concentrations of 3-12 and 12-35 μg/mL, which reflect ∼3-12 and 12-35 glasses/month of wine, were associated with lower CVD risk [HR 0.62 (95% CI 0.38; 1.00), P = .050 and HR 0.50 (95% CI 0.27; 0.95), P = .035, respectively]. Less significant associations between self-reported wine consumption and CVD risk were observed. Conclusions: Light-to-moderate wine consumption, measured through an objective biomarker (tartaric acid), was prospectively associated with lower CVD rate in a Mediterranean population at high cardiovascular risk.
• dc.description.sponsorship This research has been supported by the Comisión Interministerial de Ciencia y Tecnología [PID2020-114022RB-I00], CIBEROBN from the Instituto de Salud Carlos III from the Ministerio de Ciencia, Innovación y Universidades, National Institutes of Health (NIH) [2R01HL118264-09 and 5R01HL118264-08], (Agencia Estatal de Investigación/Fondo Europeo de Desarrollo Regional, European Union) and Generalitat de Catalunya (GC) [2017SGR 196] and FIVIN (FB 600390), and Interprofesional del vino de España-OIVE (FB 600390). INSA-UB is Maria de Maeztu Unit of Excellence (grant CEX2021-001234-M funded by Ministerio de Ciencia e Innovación (MICIN)/AEI/FEDER, UE). M.Á.M.-G. is the PI of the European Research Grant #101097681 (AdRG UNATI, 2023-2028) for a large non-inferiority trial on moderate alcohol vs. abstention. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
• dc.format.mimetype application/pdf
• dc.identifier.citation Domínguez-López I, Lamuela-Raventós RM, Razquin C, Arancibia-Riveros C, Galkina P, Salas-Salvadó J, Alonso-Gómez ÁM, Fitó M, Fiol M, Lapetra J, Gómez-Gracia E, Sorlí JV, Ruiz-Canela M, Castañer O, Liang L, Serra-Majem L, Hu FB, Ros E, Martínez-González MÁ, Estruch R. Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial. Eur Heart J. 2025 Jan 7;46(2):161-72. DOI: 10.1093/eurheartj/ehae804
• dc.identifier.doi http://dx.doi.org/10.1093/eurheartj/ehae804
• dc.identifier.issn 0195-668X
• dc.identifier.uri http://hdl.handle.net/10230/71868
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof European Heart Journal. 2025;46(2):161-72
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-114022RB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101097681
• dc.rights © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Biomarker
• dc.subject.keyword Cardiovascular disease
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword Tartaric acid
• dc.subject.keyword Wine
• dc.title Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion