Maternal asthma and newborn DNA methylation

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• dc.contributor.author Pedersen, Casper-Emil Tingskov
• dc.contributor.author Sangüesa, Júlia
• dc.contributor.author Bustamante Pineda, Mariona
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Bønnelykke, Klaus
• dc.date.accessioned 2025-06-23T06:39:52Z
• dc.date.available 2025-06-23T06:39:52Z
• dc.date.issued 2025
• dc.description.abstract Background: Prenatal exposure to maternal asthma may influence DNA methylation patterns in offspring, potentially affecting their susceptibility to later diseases including asthma. Objective: To investigate the relationship between parental asthma and newborn blood DNA methylation. Methods: Epigenome-wide association analyses were conducted in 13 cohorts on 7433 newborns with blood methylation data from the Illumina450K or EPIC array. We used fixed effects meta-analyses to identify differentially methylated CpGs (DMCs) and comb-p to identify differentially methylated regions (DMRs) associated with maternal asthma during pregnancy and maternal asthma ever. Paternal asthma was analyzed for comparison. Models were adjusted for covariates and cell-type composition. We examined whether implicated sites related to gene expression analyses in publicly available data for childhood blood and adult lung. Results: We identified 27 CpGs associated with maternal asthma during pregnancy at False Discovery Rate < 0.05 but none for maternal asthma ever. Two distinct CpGs were associated with paternal asthma. We observed 5 DMRs associated with maternal asthma during pregnancy 3 associated with maternal asthma ever and 13 DMRs associated with paternal asthma. Gene expression analysis using data in blood from 832 children and lung from 424 adults showed associations between identified DMCs using maternal asthma and expression of several genes, including HLA genes and HOXA5, previously implicated in asthma or lung function. Conclusion: Parental asthma, especially maternal asthma during pregnancy, may be associated with alterations in newborn DNA methylation. These findings might shed light on underlying mechanisms for asthma susceptibility.
• dc.description.sponsorship Open access funding provided by the National Institutes of Health. C-ETP and KB are part of COPSAC and funded by The Lundbeck Foundation (Grant no R16-A1694); The Ministry of Health (Grant no 903516); Danish Council for Strategic Research (Grant no 0603-00280B) and The Capital Region Research Foundation have provided core support to the COPSAC research center. SJL is funded by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (ES 49019). LD received funding for projects from the European Union’s Horizon 2020 research and innovation program (LIFECYCLE, grant agreement No 733206, 2016 EUCAN-Connect grant agreement No 824989 ATHLETE, grant agreement No 874583 ENDOMIX No 101136566). AS was funded by the Lundbeck foundation and the Independent Research Fund Denmark. DS was funded by the Lundbeck foundation, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Environmental Health Sciences, National Institute of Neurological Disorders and Stroke and the Beatrice and Samuel A. Seaver Foundation. NHS was funded by the Lundbeck foundation. HRE, RG work in the Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK, which is supported by the Medical Research Council and the University of Bristol (MC_UU_00011/5). The funding bodies had no role in the design of the study. Cohort-specific funding is mentioned in supplementary material. The researchers are independent from the funders. The study sponsors had no role in the study design, data analysis, interpretation of data or writing of this study.
• dc.format.mimetype application/pdf
• dc.identifier.citation Pedersen CT, Hoang TT, Jin J, Starnawska A, Granell R, Elliott HR, et al. Maternal asthma and newborn DNA methylation. Clin Epigenetics. 2025 May 10;17(1):79. DOI: 10.1186/s13148-025-01858-4
• dc.identifier.doi http://dx.doi.org/10.1186/s13148-025-01858-4
• dc.identifier.issn 1868-7075
• dc.identifier.uri http://hdl.handle.net/10230/70743
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.relation.ispartof Clin Epigenetics. 2025 May 10;17(1):79
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/824989
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101136566
• dc.rights © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Asma
• dc.subject.other ADN
• dc.title Maternal asthma and newborn DNA methylation
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion