State of art of cancer pharmacogenomics in Latin American populations
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- dc.contributor.author López-Cortés, Andrés
- dc.contributor.author Guerrero, Santiago, 1957-
- dc.contributor.author Redal, María Ana
- dc.contributor.author Alvarado, Angel Tito
- dc.contributor.author Quiñones, Luis
- dc.date.accessioned 2024-02-20T07:25:48Z
- dc.date.available 2024-02-20T07:25:48Z
- dc.date.issued 2017
- dc.description.abstract Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.
- dc.format.mimetype application/pdf
- dc.identifier.citation López-Cortés A, Guerrero S, Redal MA, Alvarado AT, Quiñones LA. State of art of cancer pharmacogenomics in Latin American populations. International Journal of Molecular Sciences. 2017 Jun;18(6):639. DOI: 10.3390/ijms18060639
- dc.identifier.doi http://dx.doi.org/10.3390/ijms18060639
- dc.identifier.issn 1422-0067
- dc.identifier.uri http://hdl.handle.net/10230/59168
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof International Journal of Molecular Sciences. 2017 Jun;18(6):639
- dc.rights © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cancer
- dc.subject.keyword Single nucleotide polymorphism
- dc.subject.keyword Precision medicine
- dc.subject.keyword Latin America
- dc.subject.keyword Pharmacogenetics
- dc.subject.keyword Pharmacogenomics
- dc.title State of art of cancer pharmacogenomics in Latin American populations
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion