Alternative transcriptional regulation in genome-reduced bacteria
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- dc.contributor.author Miravet Verde, Samuel, 1992-ca
- dc.contributor.author Lloréns Rico, Verónica, 1989-ca
- dc.contributor.author Serrano Pubull, Luis, 1982-ca
- dc.date.accessioned 2018-05-25T07:40:24Z
- dc.date.available 2018-05-25T07:40:24Z
- dc.date.issued 2017
- dc.description.abstract Transcription is a core process of bacterial physiology, and as such it must be tightly controlled, so that bacterial cells maintain steady levels of each RNA molecule in homeostasis and modify them in response to perturbations. The major regulators of transcription in bacteria (and in eukaryotes) are transcription factors. However, in genome-reduced bacteria, the limited number of these proteins is insufficient to explain the variety of responses shown upon changes in their environment. Thus, alternative regulators may play a central role in orchestrating RNA levels in these microorganisms. These alternative mechanisms rely on intrinsic features within DNA and RNA molecules, suggesting they are ancestral mechanisms shared among bacteria that could have an increased relevance on transcriptional regulation in minimal cells. In this review, we summarize the alternative elements that can regulate transcript abundance in genome-reduced bacteria and how they contribute to the RNA homeostasis at different levels.
- dc.description.sponsorship We acknowledge support of the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under agreement No 670216 (MYCOCHASSIS) and the Spanish Ministry of Economy and Competitiveness, 'Centro de Excelencia Severo Ochoa 2013-2017′.
- dc.format.mimetype application/pdf
- dc.identifier.citation Miravet-Verde S, Lloréns-Rico V, Serrano L. Alternative transcriptional regulation in genome-reduced bacteria. Curr Opin Microbiol. 2017 Oct;39:89-95. DOI: 10.1016/j.mib.2017.10.022
- dc.identifier.doi http://dx.doi.org/10.1016/j.mib.2017.10.022
- dc.identifier.issn 1369-5274
- dc.identifier.uri http://hdl.handle.net/10230/34722
- dc.language.iso eng
- dc.publisher Elsevierca
- dc.relation.ispartof Current Opinion in Microbiology. 2017 Oct;39:89-95
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/670216
- dc.rights © 2017 The Authors. Published by Elsevier Ltd. This is anopen access article under the CC BY-NC-ND license (http://creative-commons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Genetic transcription
- dc.subject.keyword Transcriptional regulation
- dc.subject.keyword Bacterial physiological phenomena
- dc.subject.keyword Transcription factor
- dc.title Alternative transcriptional regulation in genome-reduced bacteriaca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion