Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health

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• dc.contributor.author Ostrander, Elaine A.
• dc.contributor.author Wang, Guo-Dong
• dc.contributor.author Larson, Greger
• dc.contributor.author vonHoldt, Bridgett M.
• dc.contributor.author Davis, Brian W.
• dc.contributor.author Jagannathan, Vidhya
• dc.contributor.author Hitte, Christophe
• dc.contributor.author Wayne, Robert K.
• dc.contributor.author Zhang, Ya-Ping
• dc.contributor.author Dog10K Consortium
• dc.date.accessioned 2023-01-24T07:17:34Z
• dc.date.available 2023-01-24T07:17:34Z
• dc.date.issued 2019
• dc.description.abstract Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.
• dc.description.sponsorship This work was supported by a number of entities including grants from the Breakthrough Project of the Strategic Priority Program of the Chinese Academy of Sciences (CAS) (XDB13000000 to G-DW); the National Natural Science Foundation of China (91731304, 31621062); the Intramural Program of the National Human Genome Research Institute of the National Institutes of Health, USA (to EAO); a CAS international collaborating grant proposal (152453KYSB20150002 to G-DW); the Morris Animal Foundation (to RKW); the Swedish Research Council (to KLT); the European Research Council (ERC-2013-StG-337574-UNDEAD to GL and LF); the Natural Environmental Research Council (NE/K005243/1 and NE/K003259/1 to GL and LF); grant ‘Cani-DNA_CRB’ (ANR-11-INBS-0003) for the French Tissue Bank (to CA and CH); and a Young Innovation Promotion Association Award (to G-DW).
• dc.format.mimetype application/pdf
• dc.identifier.citation Ostrander EA, Wang GD, Larson G, vonHoldt BM, Davis BW, Jagannathan V, et al. Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health. National Science Review. 2019 Jul;6(4):810-24. DOI: 10.1093/nsr/nwz049
• dc.identifier.doi http://dx.doi.org/10.1093/nsr/nwz049
• dc.identifier.issn 2095-5138
• dc.identifier.uri http://hdl.handle.net/10230/55409
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof National Science Review. 2019 Jul;6(4):810-24
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/337574
• dc.rights © The Author(s) 2019. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Genomics
• dc.subject.keyword Genome-wide association studies (GWAS)
• dc.subject.keyword Breed
• dc.subject.keyword Selection
• dc.subject.keyword Variation
• dc.subject.keyword Evolution
• dc.title Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion