Clinical features of chronic spontaneous urticaria that predict disease prognosis and refractoriness to standard treatment
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- dc.contributor.author Curto-Barredo, Laia
- dc.contributor.author Riba Archilla, Laura
- dc.contributor.author Roura Vives, Guillem
- dc.contributor.author Pujol Vallverdú, Ramon Maria
- dc.contributor.author Giménez Arnau, Anna Maria
- dc.date.accessioned 2019-02-13T08:16:57Z
- dc.date.available 2019-02-13T08:16:57Z
- dc.date.issued 2018
- dc.description.abstract Chronic spontaneous urticaria (CSU) is characterized by heterogeneous activity, evolution, associated comorbidities and response to treatment. The aim of this study was to identify prognostic factors in patients with CSU that predict disease course and response to standard treatments. An observational retrospective study was conducted in a cohort of 549 patients with CSU, comparing patients with isolated CSU and those with CSU with concomitant inducible urticaria (CSU-CIndU). The factors associated with a worse prognosis in terms of duration and/or CSU activity and its episodes were: multiple episodes of CSU (19.2% had more than one lifetime episode of CSU), late-onset (63.6% of patients developed first onset of CSU after the age of 45 years), concomitant CIndU (20.2%) and functional serum autoreactivity. Patients with CSU-CIndU required more frequent therapy after 5 years and higher doses of 2nd-generation H1-antihistamines. Of patients with a baseline Urticaria Activity Score 7 (UAS7) between 16 and 42, 84.6% required cyclosporine or omalizumab to achieve symptom control, compared with 15.4% of patients with a baseline UAS7 between 0 and 15 (p?=?0.0013). Baseline CSU activity is the only factor found to be predictive for refractoriness to treatment with H1-antihistamines.
- dc.format.mimetype application/pdf
- dc.identifier.citation Curto-Barredo L, Archilla LR, Vives GR, Pujol RM, Giménez-Arnau AM. Clinical features of chronic spontaneous urticaria that predict disease prognosis and refractoriness to standard treatment. Acta Derm Venereol. 2018 Jul 11;98(7):641-647. DOI: 10.2340/00015555-2941
- dc.identifier.doi http://dx.doi.org/10.2340/00015555-2941
- dc.identifier.issn 0001-5555
- dc.identifier.uri http://hdl.handle.net/10230/36573
- dc.language.iso eng
- dc.publisher Society for Publication of Acta Dermato-Venereologica
- dc.relation.ispartof Acta Dermato-Venereologica. 2018 Jul 11;98(7):641-7
- dc.rights Journal Compilation © 2018 Acta Dermato-Venereologica. This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.other Urticària -- Tractament
- dc.title Clinical features of chronic spontaneous urticaria that predict disease prognosis and refractoriness to standard treatment
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion