Carotid artery stiffness and risk of vascular events and mortality: the REGICOR study

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• dc.contributor.author Elosua Llanos, Roberto
• dc.contributor.author Toloba, Andrea
• dc.contributor.author Arnold, Roman
• dc.contributor.author Groot, Eric de
• dc.contributor.author Martí-Lluch, Ruth
• dc.contributor.author Degano, Irene R.
• dc.contributor.author Marrugat de la Iglesia, Jaume
• dc.contributor.author Ramos, Rafel
• dc.date.accessioned 2024-06-03T06:30:41Z
• dc.date.issued 2024
• dc.description.abstract Introduction and objectives: The aims of this study were to determine the dose-response association of carotid arterial stiffness with vascular outcomes and overall mortality, and to assess their added predictive capacity. Methods: Population-based cohort study including 6468 individuals, with a median follow-up of 6.5 years. Six carotid artery stiffness indices were assessed: strain, stiffness, Peterson elasticity coefficient, compliance coefficient, distensibility coefficient, and pulse wave velocity (PWV). Incident coronary, cerebrovascular, global vascular, and total fatal events were identified. Results: Carotid compliance and distensibility coefficients were not associated with any of the outcomes. Carotid stiffness, Peterson elasticity coefficient, and PWV showed a direct linear relationship to cerebrovascular disease: the risk increased by 8% (95%CI, 1-16) per stiffness unit increase, by 7% (95%CI, 2-13) per 10-unit Peterson elasticity coefficient increase, and by 26% (95%CI, 8-48) per PWV unit increase. Carotid strain showed a nonlinear association with ischemic heart disease. When strain was ≤ 0.09 units, each 0.01-unit increase was associated with a 15% lower risk of coronary events (95%CI,-33 to 6); above 0.09 units, each 0.01 increase in strain was associated with a 16% higher risk of coronary events (95%CI, 6-27). The addition of the stiffness indices did not improve the predictive capacity of validated risk functions. Conclusions: Carotid stiffness, Peterson elasticity coefficient, and PWV have a direct linear association with cerebrovascular disease risk. Carotid strain is not linearly related to U-shaped ischemic heart disease risk. The inclusion of these indexes does not improve the predictive capacity of risk functions.
• dc.format.mimetype application/pdf
• dc.identifier.citation Elosua R, Toloba A, Arnold R, Groot E, Martí-Lluch R, Degano IR, et al. Carotid artery stiffness and risk of vascular events and mortality: the REGICOR study. Rev Esp Cardiol (Engl Ed). 2024 Apr;77(4):314-23. DOI: 10.1016/j.rec.2023.09.004
• dc.identifier.doi http://dx.doi.org/10.1016/j.rec.2023.09.004
• dc.identifier.issn 1885-5857
• dc.identifier.uri http://hdl.handle.net/10230/60330
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Rev Esp Cardiol (Engl Ed). 2024 Apr;77(4):314-23
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.rec.2023.09.004
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Carotid stiffness
• dc.subject.keyword Ischemic heart disease
• dc.subject.keyword Cerebrovascular disease
• dc.subject.keyword Predictive capacity
• dc.title Carotid artery stiffness and risk of vascular events and mortality: the REGICOR study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion