Synthetic ecosystems: From the test tube to the biosphere

Solé Vicente, Ricard, 1962-; Maull, Victor; Amor, Daniel R.; Pla, Jordi; Conde Pueyo, Núria, 1983-

doi:http://dx.doi.org/10.1021/acssynbio.4c00384

Synthetic ecosystems: From the test tube to the biosphere

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Solé R, Maull V, Amor DR, Pla Mauri J, Conde-Pueyo N. Synthetic ecosystems: From the test tube to the biosphere. ACS Synth Biol. 2024 Dec 20;13(12):3812-26. DOI: 10.1021/acssynbio.4c00384

Abstract

The study of ecosystems, both natural and artificial, has historically been mediated by population dynamics theories. In this framework, quantifying population numbers and related variables (associated with metabolism or biological-environmental interactions) plays a central role in measuring and predicting system-level properties. As we move toward advanced technological engineering of cells and organisms, the possibility of bioengineering ecosystems (from the gut microbiome to wildlands) opens several questions that will require quantitative models to find answers. Here, we present a comprehensive survey of quantitative modeling approaches for managing three kinds of synthetic ecosystems, sharing the presence of engineered strains. These include test tube examples of ecosystems hosting a relatively low number of interacting species, mesoscale closed ecosystems (or ecospheres), and macro-scale, engineered ecosystems. The potential outcomes of synthetic ecosystem designs and their limits will be relevant to different disciplines, including biomedical engineering, astrobiology, space exploration and fighting climate change impacts on endangered ecosystems. We propose a space of possible ecosystems that captures this broad range of scenarios and a tentative roadmap for open problems and further exploration.