Measurement properties of the EQ-5D-Y administered through a smartphone app in children with asthma: a longitudinal questionnaire study

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• dc.contributor.author Mayoral, Karina
• dc.contributor.author Garin Boronat, Olatz, 1979-
• dc.contributor.author Lizano-Barrantes, Catalina
• dc.contributor.author Pont Acuña, Àngels
• dc.contributor.author Caballero-Rabasco, María Araceli
• dc.contributor.author Praena-Crespo, Manuel
• dc.contributor.author Valdesoiro-Navarrete, Laura
• dc.contributor.author Guerra, María Teresa
• dc.contributor.author Castillo, José
• dc.contributor.author Mir, Inés de
• dc.contributor.author Tato, Eva
• dc.contributor.author Alonso Caballero, Jordi
• dc.contributor.author Serra-Sutton, Vicky
• dc.contributor.author Pardo Cladellas, Yolanda
• dc.contributor.author Ferrer Forés, Maria Montserrat
• dc.contributor.author ARCA Group
• dc.date.accessioned 2022-06-13T06:11:36Z
• dc.date.available 2022-06-13T06:11:36Z
• dc.date.issued 2022
• dc.description.abstract Background: Asthma impacts children's physical, emotional, and psychosocial Health-Related Quality of Life (HRQL). The EQ-5D-Y is a generic econometric instrument developed to measure HRQL in children. Objective: Evaluation of feasibility, validity, reliability, and responsiveness of EQ-5D-Y descriptive system and utility index to allow the assessment of HRQL in children with asthma, aged 8-11 years (self-response version) or under 8 years old (proxy-response version). Methods: We used data from baseline to 10 months of follow-up of an observational, prospective study of children with persistent asthma recruited by pediatricians in Spain (2018-2020). HRQL instruments were administered through a smartphone application: ARCA app. The EQ-5D-Y is composed of a 5-dimension descriptive system, a utility index ranging from 1 to - 0.5392, and a general health visual analogue scale (EQ-VAS). The Pediatric Asthma Impact Scale (PROMIS-PAIS) includes 8 items, providing a raw score. Construct validity hypotheses were stated a priori, and evaluated following two approaches, multitrait-multimethod matrix and known groups' comparisons. Reliability and responsiveness subsamples were defined by stability or change in EQ-VAS and the Asthma Control Questionnaire (ACQ), to estimate the intraclass correlation coefficient (ICC) and the magnitude of change over time. Results: The EQ-5D-Y was completed at baseline for 119 children (81 self-responded and 38 through proxy response), with a mean age of 9.1 (1.7) years. Mean (SD) of the EQ-5D-Y utility index was 0.93 (0.11), with ceiling and floor effects of 60.3% and 0%, respectively. Multitrait-multimethod matrix confirmed the associations previously hypothesized for the EQ-5D-Y utility index [moderate with PROMIS-PAIS (0.38) and weak with ACQ (0.28)], and for the EQ-5D-Y dimension "problems doing usual activities" [moderate with the ACQ item (0.35) and weak with the PROMIS-PAIS item (0.17)]. Statistically significant differences were found in the EQ-5D-Y between groups defined by asthma control, reliever inhalers use, and second-hand smoke exposure, with mostly moderate effect sizes (0.45-0.75). The ICC of the EQ-5D-Y utility index in the stable subsamples was high (0.81 and 0.79); and responsiveness subsamples presented a moderate to large magnitude of change (0.68 and 0.78), though without statistical significance. Conclusions: These results support the use of the EQ-5D-Y as a feasible, valid, and reliable instrument for evaluating HRQL in children with persistent asthma. Further studies are needed on the responsiveness of the EQ-5D-Y in this population.
• dc.format.mimetype application/pdf
• dc.identifier.citation Mayoral K, Garin O, Lizano-Barrantes C, Pont A, Caballero-Rabasco AM, Praena-Crespo M, Valdesoiro-Navarrete L, Guerra MT, Castillo JA, Mir I, Tato E, Alonso J, Serra-Sutton V, Pardo Y, Ferrer M; ARCA Group. Measurement properties of the EQ-5D-Y administered through a smartphone app in children with asthma: a longitudinal questionnaire study. Health Qual Life Outcomes. 2022 Mar 28;20(1):51. DOI: 10.1186/s12955-022-01955-5
• dc.identifier.doi http://dx.doi.org/10.1186/s12955-022-01955-5
• dc.identifier.issn 1477-7525
• dc.identifier.uri http://hdl.handle.net/10230/53465
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.relation.ispartof Health Qual Life Outcomes. 2022 Mar 28;20(1):51
• dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Asthma
• dc.subject.keyword EQ-5D-Y
• dc.subject.keyword Health-Related Quality of Life
• dc.subject.keyword Reliability
• dc.subject.keyword Responsiveness
• dc.subject.keyword Smartphone app
• dc.subject.keyword Validity
• dc.title Measurement properties of the EQ-5D-Y administered through a smartphone app in children with asthma: a longitudinal questionnaire study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion