Muscle-tendon weakness contributes to chronic fatigue syndrome in Gaucher's disease
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- dc.contributor.author Roca-Espiau, Mercedes
- dc.contributor.author Andrade-Campos, Marcio
- dc.contributor.author Cebolla, Jorge J.
- dc.contributor.author López de Frutos, Laura
- dc.contributor.author Medrano-Engay, Blanca
- dc.contributor.author López-Royo, Maria-Pilar
- dc.contributor.author Giraldo, Pilar
- dc.date.accessioned 2021-03-12T07:49:09Z
- dc.date.available 2021-03-12T07:49:09Z
- dc.date.issued 2019
- dc.description.abstract Background: Chronic fatigue (CFg) is a prevalent symptom in Gaucher disease (GD) at diagnosis (79%) and remains in a quarter of patients after years of therapy. Bone abnormalities are present in over 70% and peripheral neuropathy in about 11% of the patients, which contributes to the disabling and debilitating complications. Our hypothesis is that other factors such as muscle-tendinous weakness could have influence in the development of CFg. Methods: We have evaluated the fiber structure and elasticity of muscle-tendinous unit by strain-elastography (S-ELA) and analyzed their influence in the CFg. S-ELA study was performed in Achilles tendon in 25 type 1 and two type 3 GD patients, all of them with fatigue and were on enzymatic replacement therapy for mean 13 years; simultaneously, bone marrow burden by MRI and calcaneus ultrasound densitometry were evaluated. Blood cell counts, plasma biomarkers, GBA1 genotyping, and SF36 quality of life scale (QoL) were also performed. Statistical analysis: descriptive and comparative test. Results: All patients showed a normal Achilles tendinous structure. Abnormal stiff grade 2-3 was found in 17/27 (62.9%); in 11/27 (40.7%) of patients, the alteration was bilateral. There were no correlations between the S-ELA results to other variables; nevertheless, a significant correlation between the degree of tendon hardness and the low score on the QoL scales (p = 0.0035) was found. The S-ELA is a sensitive painless, fast, and low cost method to detect muscle-tendinous subclinical dysfunction that could contribute to CFg in GD. The identification of subclinical tendon alteration would be a sign of alarm, focused on the risk of development of bone complications. Conclusion: Intratendinous alteration in strain-elastography is an independent variable in GD patients with persistent fatigue.
- dc.format.mimetype application/pdf
- dc.identifier.citation Roca-Espiau M, Andrade-Campos M, Cebolla JJ, López de Frutos L, Medrano-Engay B, López-Royo MP, et al. Muscle-tendon weakness contributes to chronic fatigue syndrome in Gaucher's disease. J Orthop Surg Res. 2019 Nov 21; 14(1): 383. DOI: 10.1186/s13018-019-1452-y
- dc.identifier.doi http://dx.doi.org/10.1186/s13018-019-1452-y
- dc.identifier.issn 1749-799X
- dc.identifier.uri http://hdl.handle.net/10230/46743
- dc.language.iso eng
- dc.publisher BioMed Central
- dc.rights Copyright © The Author(s). 2019. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Achilles tendon stiffness
- dc.subject.keyword Fatigue
- dc.subject.keyword Gaucher disease
- dc.subject.keyword QoL
- dc.subject.keyword Strain-elastography
- dc.title Muscle-tendon weakness contributes to chronic fatigue syndrome in Gaucher's disease
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion