Skin microbiome modulation induced by probiotic solutions

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• dc.contributor.author Paetzold, Bernhard, 1981-
• dc.contributor.author Willis, Jesse R.
• dc.contributor.author Pereira de Lima, Joao
• dc.contributor.author Knödlseder, Nastassia
• dc.contributor.author Brüggemann, Holger
• dc.contributor.author Quist, Sven Roy
• dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
• dc.contributor.author Güell Cargol, Marc, 1982-
• dc.date.accessioned 2019-07-05T07:16:21Z
• dc.date.available 2019-07-05T07:16:21Z
• dc.date.issued 2019
• dc.description.abstract Background: The skin is colonized by a large number of microorganisms, most of which are beneficial or harmless. However, disease states of skin have specific microbiome compositions that are different from those of healthy skin. Gut microbiome modulation through fecal transplant has been proven as a valid therapeutic strategy in diseases such as Clostridium difficile infections. Therefore, techniques to modulate the skin microbiome composition may become an interesting therapeutic option in diseases affecting the skin such as psoriasis or acne vulgaris. Methods: Here, we have used mixtures of different skin microbiome components to alter the composition of recipient skin microbiomes. Results: We show that after sequential applications of a donor microbiome, the recipient microbiome becomes more similar to the donor. After intervention, an initial week-long phase is characterized by the dominance of donor strains. The level of engraftment depends on the composition of the recipient and donor microbiomes, and the applied bacterial load. We observed higher engraftment using a multi-strain donor solution with recipient skin rich in Cutibacterium acnes subtype H1 and Leifsonia. Conclusions: We have demonstrated the use of living bacteria to modulate skin microbiome composition.
• dc.format.mimetype application/pdf
• dc.identifier.citation Paetzold B, Willis JR, Pereira de Lima J, Knödlseder N, Brüggemann H, Quist SR et al. Skin microbiome modulation induced by probiotic solutions. Microbiome. 2019;7(1):95. DOI: 10.1186/s40168-019-0709-3
• dc.identifier.doi http://dx.doi.org/10.1186/s40168-019-0709-3
• dc.identifier.issn 2049-2618
• dc.identifier.uri http://hdl.handle.net/10230/41952
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.relation.ispartof Microbiome. 2019;7(1):95
• dc.rights © The Author(s). 2019 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cutibacterium acnes
• dc.subject.keyword Microbiome transplantation
• dc.subject.keyword Skin microbiome
• dc.title Skin microbiome modulation induced by probiotic solutions
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion