HIPPIE v2.0: Enhancing meaningfulness and reliability of protein-protein interaction networks

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  • dc.contributor.author Alanis-Lobato, Gregorioca
  • dc.contributor.author Andrade-Navarro, Miguel A.ca
  • dc.contributor.author Schaefer, Martin H.ca
  • dc.date.accessioned 2018-06-28T07:40:38Z
  • dc.date.available 2018-06-28T07:40:38Z
  • dc.date.issued 2017
  • dc.description.abstract The increasing number of experimentally detected interactions between proteins makes it difficult for researchers to extract the interactions relevant for specific biological processes or diseases. This makes it necessary to accompany the large-scale detection of protein-protein interactions (PPIs) with strategies and tools to generate meaningful PPI subnetworks. To this end, we generated the Human Integrated Protein-Protein Interaction rEference or HIPPIE (http://cbdm.uni-mainz.de/hippie/). HIPPIE is a one-stop resource for the generation and interpretation of PPI networks relevant to a specific research question. We provide means to generate highly reliable, context-specific PPI networks and to make sense out of them. We just released the second major update of HIPPIE, implementing various new features. HIPPIE grew substantially over the last years and now contains more than 270 000 confidence scored and annotated PPIs. We integrated different types of experimental information for the confidence scoring and the construction of context-specific networks. We implemented basic graph algorithms that highlight important proteins and interactions. HIPPIE's graphical interface implements several ways for wet lab and computational scientists alike to access the PPI data.
  • dc.description.sponsorship German Research Foundation [SCHA 1933/1-1]; Spanish Ministry of Economy and Competitiveness, 'Centro de Excelencia Severo Ochoa 2013-2017' [SEV-2012-0208]; European Union Seventh Framework Programme (FP7/2007-2013) [n° HEALTH-F4-2011-278568 (PRIMES)]; Spanish Ministerio de Economía y Competitividad [Plan Nacional BIO2012-39754]; European Fund for Regional Development (EFRD). Funding for open access charge: University of Mainz.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Alanis-Lobato G, Andrade-Navarro MA, Schaefer MH. HIPPIE v2.0: enhancing meaningfulness and reliability of protein-protein interaction networks. Nucleic Acids Res. 2017 Jan 4;45(D1):D408-D414. DOI: 10.1093/nar/gkw985
  • dc.identifier.doi http://dx.doi.org/10.1093/nar/gkw985
  • dc.identifier.issn 0305-1048
  • dc.identifier.uri http://hdl.handle.net/10230/34994
  • dc.language.iso eng
  • dc.publisher Oxford University Pressca
  • dc.relation.ispartof Nucleic Acids Research. 2017 Jan 4;45(D1):D408-D414
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/278568
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-39754
  • dc.rights © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.subject.keyword Computational biology
  • dc.subject.keyword Protein interaction mapping
  • dc.title HIPPIE v2.0: Enhancing meaningfulness and reliability of protein-protein interaction networksca
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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