CD4+CCR5+ T cells and CCL3+ mast cells are increased in the skin of patients with chronic spontaneous urticaria
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Mubariki, Raeda
- dc.contributor.author Samara, Reem
- dc.contributor.author Giménez Arnau, Anna Maria
- dc.contributor.author Maurer, Marcus
- dc.contributor.author Bejar, Jacob
- dc.contributor.author Toubi, Elias
- dc.contributor.author Vadasz, Zahava
- dc.date.accessioned 2025-05-27T06:28:55Z
- dc.date.available 2025-05-27T06:28:55Z
- dc.date.issued 2024
- dc.description.abstract Background: The proximity of activated T cells and mast cells in the lesional skin of patients with chronic spontaneous urticaria (CSU) is held to contribute to the development of wheals and angioedema. In a previous study, we demonstrated that increased IL-17 expression in T cells and mast cells in skin lesions of patients with CSU is associated with T/mast cell proximity, but the mechanisms that drive T cell/mast cell co-localization remain unknown. Objectives: To assess if chemokines expressed in lesional CSU skin contribute to T cell/mast cell proximity. Patients and methods: Biopsies from lesional CSU skin were compared to biopsies from healthy skin for expression of CCR5 and its ligand CCL3 by CD4+ T cells and mast cells, respectively. Results: Numbers of CCR5-positive CD4+ T cells in lesional CSU skin were significantly increased as compared to healthy normal skin (p < 0.0001). The number of mast cells expressing CCL3 (ligand for CCR5) in CSU skin was also increased (p < 0.0002) and significant association with T-cell close proximity (p < 0.0001) is noticed. Conclusions: The close proximity of T cells and mast cells in the skin of severe CSU may be driven, at least in part by increased CCR5 and CCL3 expression. Therapies that target CCL3 interaction with CCR5 should be assessed for their effects in CSU.
- dc.format.mimetype application/pdf
- dc.identifier.citation Mubariki R, Samara R, Gimenez-Arnua AM, Maurer M, Bejar J, Toubi E, et al. CD4+CCR5+ T cells and CCL3+ mast cells are increased in the skin of patients with chronic spontaneous urticaria. Front Immunol. 2024 Jul 22;15:1327040. DOI: 10.3389/fimmu.2024.1327040
- dc.identifier.doi http://dx.doi.org/10.3389/fimmu.2024.1327040
- dc.identifier.issn 1664-3224
- dc.identifier.uri http://hdl.handle.net/10230/70515
- dc.language.iso eng
- dc.publisher Frontiers
- dc.relation.ispartof Front Immunol. 2024 Jul 22;15:1327040
- dc.rights © 2024 Mubariki, Samara, Gimenez-Arnua, Maurer, Bejar, Toubi and Vadasz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. http://creativecommons.org/licenses/by/4.0/
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword CSU
- dc.subject.keyword T cells
- dc.subject.keyword Angioedema
- dc.subject.keyword Chemokines
- dc.subject.keyword Mast cells
- dc.subject.keyword Wheals
- dc.title CD4+CCR5+ T cells and CCL3+ mast cells are increased in the skin of patients with chronic spontaneous urticaria
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion