Associations between pre- and postnatal exposure to air pollution and lung health in children and assessment of CC16 as a potential mediator

Stapleton, Anna; Casas Sanahuja, Maribel; García Aymerich, Judith; García, Raquel; Sunyer Deu, Jordi; Guerra, Stefano; Abellan, Alicia; Lavi, Iris; Dobaño, Carlota; Vidal, Marta; Gascon Merlos, Mireia, 1984-

Associations between pre- and postnatal exposure to air pollution and lung health in children and assessment of CC16 as a potential mediator

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dc.contributor.author Stapleton, Anna
dc.contributor.author Casas Sanahuja, Maribel
dc.contributor.author García Aymerich, Judith
dc.contributor.author García, Raquel
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Guerra, Stefano
dc.contributor.author Abellan, Alicia
dc.contributor.author Lavi, Iris
dc.contributor.author Dobaño, Carlota
dc.contributor.author Vidal, Marta
dc.contributor.author Gascon Merlos, Mireia, 1984-
dc.date.accessioned 2023-10-20T06:06:53Z
dc.date.available 2023-10-20T06:06:53Z
dc.date.issued 2022
dc.description.abstract Background: Early life exposure to air pollution can affect lung health. Previous studies have not assessed the implications of both pre- and postnatal exposure to air pollutants on lung function at repeated ages during childhood. In addition, there is the need to identify potential mediators of such effect. Objectives: To longitudinally assess the association between pre- and postnatal air pollution exposure and lung function during childhood. We also aimed to explore the role of Club cell secretory protein (CC16) as a potential mediator in this association. Methodology: We included 487 mother-child pairs from the INMA (INfancia y Medio Ambiente) Sabadell birth cohort, recruited between 2004 and 2006. Air pollution exposure was estimated for pregnancy, pre-school age, and school-age using temporally adjusted land use regression (LUR) modelling. Lung function was measured at ages 4, 7, 9 and 11 by spirometry. At age 4, serum CC16 levels were determined in 287 children. Multivariable linear regression models and linear mixed modelling were applied, while considering potential confounders. Results: Prenatal exposure to Particulate Matter (PM)10 and PMcoarse had the most consistent associations with reduced lung function in cross-sectional models. Associations with postnatal exposure were less consistent. Increasing CC16 levels at 4 years were associated with an increase in FEF25-75 (β = 120.4 mL, 95% CI: 6.30, 234.5) from 4 to 11 years of age. No statistically significant associations were found between pre- or postnatal air pollution and CC16 at age 4. Conclusion: Increasing levels of air pollution exposure, particularly prenatal PM10 and PMcoarse exposure, were associated with a reduction in lung function. We were not able to confirm our hypothesis on the mediation role of CC16 in this association, however our results encourage further exploration of this possibility in future studies.
dc.description.sponsorship This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds; PI15/00118 incl. FEDER funds; CP16/00128 incl. FEDER funds; PI16/00118 incl. FEDER funds; PI16/00261 incl. FEDER funds; PI18/00547 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010; EST-2016 RF-21), EU Commission (261357, 308333, 603794 and 634453).ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. Mireia Gascon holds a Miguel Servet fellowship (Grant CP19/00183) funded by Acción Estratégica de Salud - Instituto de Salud Carlos III, co-funded by European Social Fund “Investing in your future”. ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023″ Program (CEX2018-000806-S), and support from the . through the CERCA Program.
dc.format.mimetype application/pdf
dc.identifier.citation Stapleton A, Casas M, García J, García R, Sunyer J, Guerra S, Abellan A, Lavi I, Dobaño C, Vidal M, Gascon M. Associations between pre- and postnatal exposure to air pollution and lung health in children and assessment of CC16 as a potential mediator. Environ Res. 2022 Mar;204(Pt A):111900. DOI: 10.1016/j.envres.2021.111900
dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2021.111900
dc.identifier.issn 0013-9351
dc.identifier.uri http://hdl.handle.net/10230/58104
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environ Res. 2022 Mar;204(Pt A):111900
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.keyword Air pollution
dc.subject.keyword CC16
dc.subject.keyword Children
dc.subject.keyword Lung function
dc.title Associations between pre- and postnatal exposure to air pollution and lung health in children and assessment of CC16 as a potential mediator
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/acceptedVersion

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