Spironolactone versus sympathetic renal denervation to treat true resistant hypertension: results from the DENERVHTA study - a randomized controlled trial.

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  • dc.contributor.author Oliveras, Annaca
  • dc.contributor.author Armario, Pedroca
  • dc.contributor.author Clará Velasco, Albertoca
  • dc.contributor.author Sans Atxer, Laiaca
  • dc.contributor.author Vázquez, Susanaca
  • dc.contributor.author Pascual Santos, Julioca
  • dc.contributor.author Sierra, Alejandro de laca
  • dc.date.accessioned 2017-01-16T09:40:56Z
  • dc.date.available 2017-01-16T09:40:56Z
  • dc.date.issued 2016
  • dc.description.abstract OBJECTIVE: Both renal denervation (RDN) and spironolactone have been proposed for the treatment of resistant hypertension. However, they have not been compared in a randomized clinical trial. We aimed to compare the efficacy of spironolactone versus RDN in patients with resistant hypertension. METHODS: A total of 24 patients with office SBP at least 150 mmHg and 24-h SBP at least 140 mmHg despite receiving at least three full-dose antihypertensive drugs, one a diuretic, but without aldosterone antagonists, were randomized to receive RDN or spironolactone (50 mg) as add-on therapy. Primary endpoint was change in 24-h SBP at 6 months. Comparisons between treatment groups were performed using generalized linear models adjusted by age, sex, and baseline values. RESULTS: Spironolactone was more effective than RDN in reducing 24-h SBP and 24-h DBP: mean baseline-adjusted differences between the two groups were -17.9 mmHg (95%CI -30.9 to -4.9); P = 0.010 and -6.6 mmHg (95%CI -12.9 to -0.3); P = 0.041, for 24-h SBP and 24-h DBP, respectively. As regards changes in office blood pressure, mean baseline-adjusted differences between the two groups were -12.1 mmHg (95%CI -29.1 to 5.1); P = 0.158 and of -5.3 mmHg (95%CI -16.3 to 5.8); P = 0.332, for office SBP and office DBP, respectively. Otherwise, the decrease of estimated glomerular filtration rate was greater in the spironolactone group; mean baseline-adjusted difference between the two groups was -10.7 ml/min per 1.73 m (95%CI -20.1 to -1.4); P = 0.027. CONCLUSION: We conclude that spironolactone is more effective than RDN to reduce 24-h SBP and 24-h DBP in patients with resistant hypertension. Therefore, spironolactone should be the fourth antihypertensive drug to prescribe if deemed well tolerated' in all patients with resistant hypertension before considering RDN.ca
  • dc.description.sponsorship The work was supported by the Spanish Health Authority: EC11–426.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Oliveras A, Armario P, Clarà A, Sans-Atxer L, Vázquez S, Pascual J, et al. Spironolactone versus sympathetic renal denervation to treat true resistant hypertension: results from the DENERVHTA study - a randomized controlled trial. J Hypertens. 2016 Sep;34(9):1863-71. doi: 10.1097/HJH.0000000000001025ca
  • dc.identifier.doi http://dx.doi.org/10.1097/HJH.0000000000001025
  • dc.identifier.issn 0263-6352
  • dc.identifier.uri http://hdl.handle.net/10230/27899
  • dc.language.iso engca
  • dc.publisher Lippincott Williams & Wilkinsca
  • dc.relation.ispartof Journal of Hypertension. 2016 Sep;34(9):1863-71
  • dc.rights © 2016 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ca
  • dc.subject.other Hipertensió -- Tractamentca
  • dc.title Spironolactone versus sympathetic renal denervation to treat true resistant hypertension: results from the DENERVHTA study - a randomized controlled trial.ca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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