Endoluminal radiofrequency ablation of the main pancreatic duct is a secure and effective method to produce pancreatic atrophy and to achieve stump closure

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  • dc.contributor.author Andaluz, Anna
  • dc.contributor.author Ewertowska, Elżbieta
  • dc.contributor.author Moll, Xavier
  • dc.contributor.author Aguilar, Adrià
  • dc.contributor.author García Arnas, Félix
  • dc.contributor.author Fondevila, Dolors
  • dc.contributor.author Quesada Diez, Rita
  • dc.contributor.author Berjano, Enrique J.
  • dc.contributor.author Grande, Luís
  • dc.contributor.author Burdío Pinilla, Fernando
  • dc.date.accessioned 2020-04-15T07:20:15Z
  • dc.date.available 2020-04-15T07:20:15Z
  • dc.date.issued 2019
  • dc.description.abstract Radiofrequency energy has been used both experimentally and clinically to manage the pancreatic remnant after distal pancreatectomies. Our goal was to determine whether endoluminal radiofrequency (RF) ablation of the main pancreatic duct in large animals would be more efficient than glue occlusion as an exocrine pancreatic atrophy-inducing procedure. Thirty-four Landrace pigs were assigned to either the transpapilar (n = 16) or transection (n = 18) groups. The transection implied the pancreas neck was severed. In each of these groups the remaining distal pancreatic duct was occluded either by RF or by glue. In the transpapilar group complete atrophy was observed in all the RF cases, while atrophy was incomplete in all the members of the glue subgroup. The failure rate of the main pancreatic duct (usually expressed by a pseudocyst) in the transection groups was dramatically higher in the glue subgroup than the RF subgroups (9 out of 9 and 1 out of 9, respectively) and postoperative mortality occurred only in the glue subgroup (3 out of 9). These results show the superiority of endoluminal RF ablation over glue for main pancreatic duct occlusion, as seen by the degree of atrophy and fewer postoperative pancreatic fistulas.
  • dc.description.sponsorship This work was supported by the Spanish Ministerio de Economía, Industria y Competitividad under the “Plan Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad” Grant TEC2014–52383–C3–R (TEC2014–52383–C3–1–R and TEC2014–52383–C3–3–R). Elzbieta Ewertowska has a Predoctoral Grant (BES-2015–073285) from the Ministry of Economy, Industry and Competitiveness (Government of Spain).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Andaluz A, Ewertowska E, Moll X, Aguilar A, García F, Fondevila D, et al. Endoluminal radiofrequency ablation of the main pancreatic duct is a secure and effective method to produce pancreatic atrophy and to achieve stump closure. Sci Rep. 2019 Apr 11; 9(1):5928. DOI: 10.1038/s41598-019-42411-7
  • dc.identifier.doi http://dx.doi.org/10.1038/s41598-019-42411-7
  • dc.identifier.issn 2045-2322
  • dc.identifier.uri http://hdl.handle.net/10230/44216
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BES2015–073285
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TEC2014–52383–C3–R
  • dc.rights Copyright © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Pàncrees -- Malalties
  • dc.subject.other Pancreatitis
  • dc.title Endoluminal radiofrequency ablation of the main pancreatic duct is a secure and effective method to produce pancreatic atrophy and to achieve stump closure
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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