Prenatal urban environment and blood pressure trajectories from childhood to early adulthood

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• dc.contributor.author Gonçalves Soares, Ana
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.contributor.author Fossati, Serena
• dc.contributor.author Timpson, Nicholas J.
• dc.date.accessioned 2024-06-18T06:36:41Z
• dc.date.available 2024-06-18T06:36:41Z
• dc.date.issued 2024
• dc.description.abstract Background: Prenatal urban environmental exposures have been associated with blood pressure in children. The dynamic of these associations across childhood and later ages is unknown. Objectives: The purpose of this study was to assess associations of prenatal urban environmental exposures with blood pressure trajectories from childhood to early adulthood. Methods: Repeated measures of systolic blood pressure (SBP) and diastolic blood pressure (DBP) were collected in up to 7,454 participants from a UK birth cohort. Prenatal urban exposures (n = 43) covered measures of noise, air pollution, built environment, natural spaces, traffic, meteorology, and food environment. An exposome-wide association study approach was used. Linear spline mixed-effects models were used to model associations of each exposure with trajectories of blood pressure. Replication was sought in 4 independent European cohorts (up to 9,261). Results: In discovery analyses, higher humidity was associated with a faster increase (mean yearly change in SBP for an interquartile range increase in humidity: 0.29 mm Hg/y, 95% CI: 0.20-0.39) and higher temperature with a slower increase (mean yearly change in SBP per interquartile range increase in temperature: −0.17 mm Hg/y, 95% CI: −0.28 to −0.07) in SBP in childhood. Higher levels of humidity and air pollution were associated with faster increase in DBP in childhood and slower increase in adolescence. There was little evidence of an association of other exposures with change in SBP or DBP. Results for humidity and temperature, but not for air pollution, were replicated in other cohorts. Conclusions: Replicated findings suggest that higher prenatal humidity and temperature could modulate blood pressure changes across childhood.
• dc.format.mimetype application/pdf
• dc.identifier.citation Gonçalves Soares A, Santos S, Seyve E, Nedelec R, Puhakka S, Eloranta AM, et al. Prenatal urban environment and blood pressure trajectories from childhood to early adulthood. JACC: Advances. 2024;3(2):100808. DOI: 10.1016/j.jacadv.2023.100808
• dc.identifier.doi http://dx.doi.org/10.1016/j.jacadv.2023.100808
• dc.identifier.issn 2772-963X
• dc.identifier.uri http://hdl.handle.net/10230/60502
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof JACC: Advances. 2024;3(2):100808
• dc.rights © 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword ALSPAC
• dc.subject.keyword Blood pressure
• dc.subject.keyword Cohorts
• dc.subject.keyword LongITools
• dc.subject.keyword Trajectories
• dc.subject.keyword Urban environment
• dc.title Prenatal urban environment and blood pressure trajectories from childhood to early adulthood
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion