Bacteria use structural imperfect mimicry to hijack the host interactome

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• dc.contributor.author Sanchez de Groot, Natalia
• dc.contributor.author Torrent Burgas, Marc
• dc.date.accessioned 2021-03-23T11:10:57Z
• dc.date.available 2021-03-23T11:10:57Z
• dc.date.issued 2020
• dc.description.abstract Bacteria use protein-protein interactions to infect their hosts and hijack fundamental pathways, which ensures their survival and proliferation. Hence, the infectious capacity of the pathogen is closely related to its ability to interact with host proteins. Here, we show that hubs in the host-pathogen interactome are isolated in the pathogen network by adapting the geometry of the interacting interfaces. An imperfect mimicry of the eukaryotic interfaces allows pathogen proteins to actively bind to the host's target while preventing deleterious effects on the pathogen interactome. Understanding how bacteria recognize eukaryotic proteins may pave the way for the rational design of new antibiotic molecules.
• dc.description.sponsorship Funding: Ministerio de Economía y Competitividad (MEC): Marc Torrent RYC-2012-09999; Ministerio de Economía y Competitividad (MEC): Marc Torrent SAF2015-72518-EXP; Ministerio de Economía y Competitividad (MEC): Marc Torrent SAF2017-82158-R; European Society of Clinical Microbiology and Infectious Diseases (ESCMID): Marc Torrent ESCMID-2016
• dc.format.mimetype application/pdf
• dc.identifier.citation Sanchez de Groot N, Torrent Burgas M. Bacteria use structural imperfect mimicry to hijack the host interactome. PLoS Comput Biol. 2020 Dec 4; 16(12): e1008395. DOI: 10.1371/journal.pcbi.1008395
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pcbi.1008395
• dc.identifier.issn 1553-734X
• dc.identifier.uri http://hdl.handle.net/10230/46909
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLOS Computational Biology. 2020 Dec 4;16(12):e1008395
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/RYC-2012-09999
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-72518-EXP
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-82158-R
• dc.rights © 2020 de Groot, Burgas. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.other Bacteris
• dc.subject.other Proteïnes
• dc.subject.other Proteïnes -- Pathogens
• dc.subject.other Malalties bacterianes
• dc.title Bacteria use structural imperfect mimicry to hijack the host interactome
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion