Loss of dE2F compromises mitochondrial function
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- dc.contributor.author Ambrus, Aaron M.ca
- dc.contributor.author Islam, Abul, 1978-ca
- dc.contributor.author Holmes, Katherine B.ca
- dc.contributor.author Moon, Nam Sungca
- dc.contributor.author López Bigas, Núriaca
- dc.contributor.author Benevolenskaya, Elizaveta V.ca
- dc.contributor.author Frolov, Maxim V.ca
- dc.date.accessioned 2015-11-25T18:58:21Z
- dc.date.available 2015-11-25T18:58:21Z
- dc.date.issued 2013
- dc.description.abstract E2F/DP transcription factors regulate cell proliferation and apoptosis. Here, we investigated the mechanism of the resistance of Drosophila dDP mutants to irradiation-induced apoptosis. Contrary to the prevailing view, this is not due to an inability to induce the apoptotic transcriptional program, because we show that this program is induced; rather, this is due to a mitochondrial dysfunction of dDP mutants. We attribute this defect to E2F/DP-dependent control of expression of mitochondria-associated genes. Genetic attenuation of several of these E2F/DP targets mimics the dDP mutant mitochondrial phenotype and protects against irradiation-induced apoptosis. Significantly, the role of E2F/DP in the regulation of mitochondrial function is conserved between flies and humans. Thus, our results uncover a role of E2F/DP in the regulation of mitochondrial function and demonstrate that this aspect of E2F regulation is critical for the normal induction of apoptosis in response to irradiation.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Ambrus AM, Islam AB, Holmes KB, Moon NS, Lopez-Bigas N, Benevolenskaya EV et al. Loss of dE2F compromises mitochondrial function. Developmental cell. 2013; 27(4):438-51. DOI: 10.1016/j.devcel.2013.10.002ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.devcel.2013.10.002
- dc.identifier.issn 1534-5807
- dc.identifier.uri http://hdl.handle.net/10230/25226
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Developmental cell. 2013;27(4):438-51
- dc.rights © Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.devcel.2013.10.002 that appeared in the journal Developmental Cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other ADN -- Dany
- dc.subject.other Drosòfila
- dc.title Loss of dE2F compromises mitochondrial functionca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca