SARS-CoV-2 could be spread through hospital medication dispensed to patients: a prospective observational study
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- dc.contributor.author Grau Cerrato, Santiago
- dc.contributor.author Ferrández, Olivia
- dc.contributor.author Echeverría Esnal, Daniel
- dc.contributor.author Maldonado, Rafael, 1961-
- dc.contributor.author Puig, Berta
- dc.contributor.author Ramirez, Aida
- dc.contributor.author Canal, Mireia
- dc.contributor.author Montero, Albert
- dc.contributor.author González, Cristina
- dc.contributor.author Herranz, Milagros
- dc.contributor.author Masclans Enviz, Joan Ramon
- dc.contributor.author Horcajada Gallego, Juan Pablo
- dc.contributor.author Padilla, Eduardo
- dc.date.accessioned 2022-03-18T10:53:02Z
- dc.date.available 2022-03-18T10:53:02Z
- dc.date.issued 2021
- dc.description.abstract Our objective was to analyze in vitro the persistence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in the packaging material of the drugs dispensed to hospital wards. Additionally, to evaluate if the protection with a double plastic bag prevents the contamination of the medication dispensed to an intensive care unit (ICU).On the first part, different materials containing different drugs within an ICU were sampled to confirm the lack of contamination by SARS-CoV-2. The confirmation of the virus was performed using real time reverse transcription polymerase chain reaction. As a control group, in the microbiology laboratory we inoculated the virus into the different surfaces containing the same drugs included in the first part. Samples were obtained with a sterile swab at 3, 6, 8, 10, 14, 21, and 30 days after inoculation and analyzed through real time reverse transcription polymerase chain reaction.None of the studied materials containing the drugs within an ICU was contaminated by SARS-CoV-2. In the second part, SARS-CoV-2 was found in all surfaces for up to 30 days.The use of double-bag unit-dose system to deliver medication in a pandemic seems effective to prevent the potential transmission of SARS-CoV-2. A striking SARS-CoV-2 RNA stability of up to 30 days was found in the surfaces containing the drugs.
- dc.format.mimetype application/pdf
- dc.identifier.citation Grau S, Ferrández O, Echevarría-Esnal D, Maldonado R, Puig B, Ramirez A. et al. SARS-CoV-2 could be spread through hospital medication dispensed to patients: a prospective observational study. Medicine (Baltimore). 2021 Nov 12;100(45):e27592. DOI: 10.1097/MD.0000000000027592
- dc.identifier.doi http://dx.doi.org/10.1097/MD.0000000000027592
- dc.identifier.issn 0025-7974
- dc.identifier.uri http://hdl.handle.net/10230/52717
- dc.language.iso eng
- dc.publisher Wolters Kluwer Health, Inc.
- dc.rights © 2021 Santiago Grau et al. Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0
- dc.subject.other COVID-19 (Malaltia)
- dc.subject.other Respiració
- dc.subject.other Medicaments -- Administració
- dc.title SARS-CoV-2 could be spread through hospital medication dispensed to patients: a prospective observational study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion