Screening great ape museum specimens for DNA viruses

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dc.contributor.authorHämmerle, Michelle
dc.contributor.authorGuellil, Meriam
dc.contributor.authorTrgovec-Greif, Lovro
dc.contributor.authorCheronet, Olivia
dc.contributor.authorSawyer, Susanna
dc.contributor.authorRuiz-Gartzia, Irune
dc.contributor.authorLizano González, Esther, 1974-
dc.contributor.authorRymbekova, Aigerim
dc.contributor.authorGelabert Xirinachs, Pere, 1991-
dc.contributor.authorBernardi, Paolo
dc.contributor.authorHan, Sojung
dc.contributor.authorRattei, Thomas
dc.contributor.authorSchuenemann, Verena J.
dc.contributor.authorMarquès i Bonet, Tomàs, 1975-
dc.contributor.authorGuschanski, Katerina
dc.contributor.authorCalvignac-Spencer, Sebastien
dc.contributor.authorPinhasi, Ron
dc.contributor.authorKuhlwilm, Martin
dc.date.accessioned2025-02-05T07:10:17Z
dc.date.available2025-02-05T07:10:17Z
dc.date.issued2024
dc.description.abstractNatural history museum collections harbour a record of wild species from the past centuries, providing a unique opportunity to study animals as well as their infectious agents. Thousands of great ape specimens are kept in these collections, and could become an important resource for studying the evolution of DNA viruses. Their genetic material is likely to be preserved in dry museum specimens, as reported previously for monkeypox virus genomes from historical orangutan specimens. Here, we screened 209 great ape museum specimens for 99 different DNA viruses, using hybridization capture coupled with short-read high-throughput sequencing. We determined the presence of multiple viruses within this dataset from historical specimens and obtained several near-complete viral genomes. In particular, we report high-coverage (> 18-fold) hepatitis B virus genomes from one gorilla and two chimpanzee individuals, which are phylogenetically placed within clades infecting the respective host species.
dc.description.sponsorshipThis project has been funded by the Vienna Science and Technology Fund (WWTF) [https://doi.org/10.47379/VRG20001] and by the Austrian Science Fund (FWF) [https://doi.org/10.55776/TAI729] to M.K. K.G. received support from the Swedish Research Council (VR) through Grant 2020-03398. L. T.-G. was supported by the European Union’s Horizon 2020 research and innovation program, under the Marie Skłodowska-Curie Actions Innovative Training Networks grant agreement no. 955974 (VIROINF). T.M.-B. is supported by funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 864203), Grant PID2021-126004NB-100 funded by MICIU/AEI/ https://doi.org/10.13039/501100011033 and ERDF/EU(MICIIN/FEDER, UE) and Secretaria d’Universitats i Recerca and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2021 SGR 00177). M.G. was supported by the Austrian Science Fund (FWF) [https://doi.org/10.55776/ESP162]. S.H. was supported by the Austrian Science Fund (FWF) [https://doi.org/10.55776/ESP546].
dc.format.mimetypeapplication/pdf
dc.identifier.citationHämmerle M, Guellil M, Trgovec-Greif L, Cheronet O, Sawyer S, Ruiz-Gartzia I, et al. Screening great ape museum specimens for DNA viruses. Sci Rep. 2024 Nov 30;14(1):29806. DOI: 10.1038/s41598-024-80780-w
dc.identifier.doihttp://dx.doi.org/10.1038/s41598-024-80780-w
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10230/69493
dc.language.isoeng
dc.publisherNature Research
dc.relation.ispartofSci Rep. 2024 Nov 30;14(1):29806
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/955974
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/864203
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/3PE/PID2021-126004NB-100
dc.rights© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.keywordGreat apes
dc.subject.keywordHepatitis B virus
dc.subject.keywordMuseomics
dc.subject.keywordTarget-enrichment capture
dc.subject.keywordViruses
dc.titleScreening great ape museum specimens for DNA viruses
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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