Screening great ape museum specimens for DNA viruses

Hämmerle, Michelle; Guellil, Meriam; Trgovec-Greif, Lovro; Cheronet, Olivia; Sawyer, Susanna; Ruiz-Gartzia, Irune; Lizano González, Esther, 1974-; Rymbekova, Aigerim; Gelabert Xirinachs, Pere, 1991-; Bernardi, Paolo; Han, Sojung; Rattei, Thomas; Schuenemann, Verena J.; Marquès i Bonet, Tomàs, 1975-; Guschanski, Katerina; Calvignac-Spencer, Sebastien; Pinhasi, Ron; Kuhlwilm, Martin

Screening great ape museum specimens for DNA viruses

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dc.contributor.author Hämmerle, Michelle
dc.contributor.author Guellil, Meriam
dc.contributor.author Trgovec-Greif, Lovro
dc.contributor.author Cheronet, Olivia
dc.contributor.author Sawyer, Susanna
dc.contributor.author Ruiz-Gartzia, Irune
dc.contributor.author Lizano González, Esther, 1974-
dc.contributor.author Rymbekova, Aigerim
dc.contributor.author Gelabert Xirinachs, Pere, 1991-
dc.contributor.author Bernardi, Paolo
dc.contributor.author Han, Sojung
dc.contributor.author Rattei, Thomas
dc.contributor.author Schuenemann, Verena J.
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Guschanski, Katerina
dc.contributor.author Calvignac-Spencer, Sebastien
dc.contributor.author Pinhasi, Ron
dc.contributor.author Kuhlwilm, Martin
dc.date.accessioned 2025-02-05T07:10:17Z
dc.date.available 2025-02-05T07:10:17Z
dc.date.issued 2024
dc.description.abstract Natural history museum collections harbour a record of wild species from the past centuries, providing a unique opportunity to study animals as well as their infectious agents. Thousands of great ape specimens are kept in these collections, and could become an important resource for studying the evolution of DNA viruses. Their genetic material is likely to be preserved in dry museum specimens, as reported previously for monkeypox virus genomes from historical orangutan specimens. Here, we screened 209 great ape museum specimens for 99 different DNA viruses, using hybridization capture coupled with short-read high-throughput sequencing. We determined the presence of multiple viruses within this dataset from historical specimens and obtained several near-complete viral genomes. In particular, we report high-coverage (> 18-fold) hepatitis B virus genomes from one gorilla and two chimpanzee individuals, which are phylogenetically placed within clades infecting the respective host species.
dc.description.sponsorship This project has been funded by the Vienna Science and Technology Fund (WWTF) [https://doi.org/10.47379/VRG20001] and by the Austrian Science Fund (FWF) [https://doi.org/10.55776/TAI729] to M.K. K.G. received support from the Swedish Research Council (VR) through Grant 2020-03398. L. T.-G. was supported by the European Union’s Horizon 2020 research and innovation program, under the Marie Skłodowska-Curie Actions Innovative Training Networks grant agreement no. 955974 (VIROINF). T.M.-B. is supported by funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 864203), Grant PID2021-126004NB-100 funded by MICIU/AEI/ https://doi.org/10.13039/501100011033 and ERDF/EU(MICIIN/FEDER, UE) and Secretaria d’Universitats i Recerca and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2021 SGR 00177). M.G. was supported by the Austrian Science Fund (FWF) [https://doi.org/10.55776/ESP162]. S.H. was supported by the Austrian Science Fund (FWF) [https://doi.org/10.55776/ESP546].
dc.format.mimetype application/pdf
dc.identifier.citation Hämmerle M, Guellil M, Trgovec-Greif L, Cheronet O, Sawyer S, Ruiz-Gartzia I, et al. Screening great ape museum specimens for DNA viruses. Sci Rep. 2024 Nov 30;14(1):29806. DOI: 10.1038/s41598-024-80780-w
dc.identifier.doi http://dx.doi.org/10.1038/s41598-024-80780-w
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10230/69493
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof Sci Rep. 2024 Nov 30;14(1):29806
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/955974
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/864203
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2021-126004NB-100
dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Great apes
dc.subject.keyword Hepatitis B virus
dc.subject.keyword Museomics
dc.subject.keyword Target-enrichment capture
dc.subject.keyword Viruses
dc.title Screening great ape museum specimens for DNA viruses
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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