Metabolic co-dependence gives rise to collective oscillations within biofilms

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• dc.contributor.author Liu, Jintao
• dc.contributor.author Prindle, Arthur
• dc.contributor.author Humphries, Jacqueline
• dc.contributor.author Gabaldà Sagarra, Marçal,1988-
• dc.contributor.author Asally, Munehiro
• dc.contributor.author Lee, Dong-yeon D.
• dc.contributor.author Ly, San
• dc.contributor.author García Ojalvo, Jordi
• dc.contributor.author Süel, Gürol M.
• dc.date.accessioned 2019-01-21T08:49:14Z
• dc.date.available 2019-01-21T08:49:14Z
• dc.date.issued 2015
• dc.description.abstract Cells that reside within a community can cooperate and also compete with each other for resources. It remains unclear how these opposing interactions are resolved at the population level. Here we investigate such an internal conflict within a microbial (Bacillus subtilis) biofilm community: cells in the biofilm periphery not only protect interior cells from external attack but also starve them through nutrient consumption. We discover that this conflict between protection and starvation is resolved through emergence of long-range metabolic co-dependence between peripheral and interior cells. As a result, biofilm growth halts periodically, increasing nutrient availability for the sheltered interior cells. We show that this collective oscillation in biofilm growth benefits the community in the event of a chemical attack. These findings indicate that oscillations support population-level conflict resolution by coordinating competing metabolic demands in space and time, suggesting new strategies to control biofilm growth.
• dc.description.sponsorship J.H. is supported by the UCSD Cell and Molecular Genetics Training Grant. J.G.-O. is supported by the Ministerio de Economia y Competitividad (Spain) and FEDER, under project FIS2012-37655-C02-01, and by the ICREA Academia Programme. This research was funded by the National Institutes of Health, National Institute of General Medical Sciences Grant R01 GM088428 and the National Science Foundation Grant MCB-1450867 (both to G.M.S.)
• dc.format.mimetype application/pdf
• dc.identifier.citation Liu J, Prindle A, Humphries J, Gabalda-Sagarra M, Asally M, Lee DY et al. Metabolic co-dependence gives rise to collective oscillations within biofilms. Nature. 2015 Jul 30;523(7562):550-4. DOI: 10.1038/nature14660
• dc.identifier.doi http://dx.doi.org/10.1038/nature14660
• dc.identifier.issn 0028-0836
• dc.identifier.uri http://hdl.handle.net/10230/36337
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nature. 2015 Jul 30;523(7562):550-4
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/FIS2012-37655-C02-01
• dc.rights © Springer Nature Publishing AG. Liu J, Prindle A, Humphries J, Gabalda-Sagarra M, Asally M, Lee DY et al. Metabolic co-dependence gives rise to collective oscillations within biofilms. Nature. 2015 Jul 30; 523(7562): 550-4. http://dx.doi.org/10.1038/nature14660
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Bacillus subtilis
• dc.subject.other Biofilms
• dc.title Metabolic co-dependence gives rise to collective oscillations within biofilms
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion