Diet as a source of exposure to environmental contaminants for pregnant women and children from six european countries

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  • dc.contributor.author Papadopoulou, Eleni, 1985-
  • dc.contributor.author Haug, Line Småstuen
  • dc.contributor.author Sakhi, Amrit Kaur
  • dc.contributor.author Andrušaitytė, Sandra
  • dc.contributor.author Basagaña Flores, Xavier
  • dc.contributor.author Brantsaeter, Anne Lise
  • dc.contributor.author Casas Sanahuja, Maribel
  • dc.contributor.author Fernández-Barrés, Sílvia
  • dc.contributor.author Gražulevičienė, Regina
  • dc.contributor.author Knutsen, Helle Katrine
  • dc.contributor.author Maitre, Léa
  • dc.contributor.author Meltzer, Helle Margrete
  • dc.contributor.author McEachan, Rosemary R.C.
  • dc.contributor.author Roumeliotaki, Theano
  • dc.contributor.author Slama, Rémy
  • dc.contributor.author Vafeiadi, Marina, 1983-
  • dc.contributor.author Wright, John
  • dc.contributor.author Vrijheid, Martine
  • dc.contributor.author Thomsen, Cathrine
  • dc.contributor.author Chatzi, Leda
  • dc.date.accessioned 2020-01-27T07:52:53Z
  • dc.date.available 2020-01-27T07:52:53Z
  • dc.date.issued 2019
  • dc.description.abstract Background: Pregnant women and children are especially vulnerable to exposures to food contaminants, and a balanced diet during these periods is critical for optimal nutritional status. Objectives: Our objective was to study the association between diet and measured blood and urinary levels of environmental contaminants in mother-child pairs from six European birth cohorts (n = 818 mothers and 1,288 children). Methods: We assessed the consumption of seven food groups and the blood levels of organochlorine pesticides, polybrominated diphenyl ethers, polychlorinated biphenyls (PCBs), per- and polyfluoroalkyl substances (PFAS), and heavy metals and urinary levels of phthalate metabolites, phenolic compounds, and organophosphate pesticide (OP) metabolites. Organic food consumption during childhood was also studied. We applied multivariable linear regressions and targeted maximum likelihood based estimation (TMLE). Results: Maternal high (≥ 4times/week) versus low (< 2times/week) fish consumption was associated with 15% higher PCBs [geometric mean (GM) ratio = 1.15; 95% confidence interval (CI): 1.02, 1.29], 42% higher perfluoroundecanoate (PFUnDA) (GMratio = 1.42; 95% CI: 1.20, 1.68), 89% higher mercury (Hg) (GMratio = 1.89; 95% CI: 1.47, 2.41) and a 487% increase in arsenic (As) (GMratio = 4.87; 95% CI: 2.57, 9.23) levels. In children, high (≥ 3times/week) versus low (< 1.5times/week) fish consumption was associated with 23% higher perfluorononanoate (PFNA) (GMratio = 1.23; 95% CI: 1.08, 1.40), 36% higher PFUnDA (GMratio = 1.36; 95% CI: 1.12, 1.64), 37% higher perfluorooctane sulfonate (PFOS) (GMratio = 1.37; 95% CI: 1.22, 1.54), and >200% higher Hg and As [GMratio = 3.87 (95% CI: 1.91, 4.31) and GMratio = 2.68 (95% CI: 2.23, 3.21)] concentrations. Using TMLE analysis, we estimated that fish consumption within the recommended 2-3 times/week resulted in lower PFAS, Hg, and As compared with higher consumption. Fruit consumption was positively associated with OP metabolites. Organic food consumption was negatively associated with OP metabolites. Discussion: Fish consumption is related to higher PFAS, Hg, and As exposures. In addition, fruit consumption is a source of exposure to OPs. https://doi.org/10.1289/EHP5324.
  • dc.description.sponsorship The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 308,333, the Human Early Life Exposome (HELIX) project. The Environment and Childhood (INMA) Sabadell cohort and biomarker measurements were funded by grants from Instituto de Salud Carlos III [Red INMA G03/176; CB06/02/0041; PI041436; PI081151 including Federación Española de Enfermedades Raras (FEDER) funds; PI12/01,890 including FEDER funds; CP13/00,054 including FEDER funds], CIBERESP, Generalitat de Catalunya-Consell Interdepartamental de Recerca i Innovació Tecnològica (CIRIT) 1999SGR 00,241, Generalitat de Catalunya-Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090,430), Spanish Ministry of Economy and Competitiveness (SAF2012-32,991 including FEDER funds). The Norwegian Mother, Father and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research, National Institutes of Health, National Institute of Neurological Disorders and Stroke (NIH/NINDS; grants UO1 NS 047,537-01 and UO1 NS 047,537-06A1). The Rhea cohort was financially supported by European projects [EU FP6-2003-Food-3-NewGeneris, EU FP6 STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. (project no. 211,250 Escape), EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009-single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. (proposal no. 226,285 ENRIECO), EU- FP7-HEALTH-2012 (proposal no. 308,333 HELIX)] and by the Greek Ministry of Health (Program of Prevention of Obesity and Neurodevelopmental Disorders in Preschool Children, in Heraklion District, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15). The Lithuanian Kaunas Cohort (KANC) supported by the Lithuanian Agency for Science Innovation and Technology (No. 31V-77). M.C. received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00,128). E.P. and A.L.B. received funding from the Norwegian Research Council (Project No. 268,465). R.R.C.M. and J.W. were supported by the National Institute for Health Research (NIHR) Collaborations for Leadership in Applied Health Research and Care (CLAHRC) Yorkshire and Humber (IS-CLA-0113-10,020; http://www.clahrc-yh.nihr.ac.uk). L.C. received funding from the NIH (P30ES007048) and National Institute of Environmental Health Sciences (NIEHS R21ES02890).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Papadopoulou E, Haug LS, Sakhi AK, Andrusaityte S, Basagaña X, Brantsaeter AL et al. Diet as a source of exposure to environmental contaminants for pregnant women and children from six european countries. Environ Health Perspect. 2019;127(10):107005. DOI: 10.1289/EHP5324
  • dc.identifier.doi http://dx.doi.org/10.1289/EHP5324
  • dc.identifier.issn 0091-6765
  • dc.identifier.uri http://hdl.handle.net/10230/43419
  • dc.language.iso eng
  • dc.publisher National Institute of Environmental Health Sciences
  • dc.relation.ispartof Environmental Health Perspectives. 2019;127(10):107005
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
  • dc.rights Reproduced from Environmental Health Perspectives http://dx.doi.org/10.1289/EHP5324
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.title Diet as a source of exposure to environmental contaminants for pregnant women and children from six european countries
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Departament de Medicina i Ciències de la Vida)
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