Genetic and functional characterization of disease associations explains comorbidity

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• dc.contributor.author Rubio Pérez, Carlota, 1990-ca
• dc.contributor.author Güney, Emre, 1983-ca
• dc.contributor.author Aguilar, Danielca
• dc.contributor.author Piñero González, Janet, 1977-ca
• dc.contributor.author García-García, Javier, 1982-ca
• dc.contributor.author Iadarola, Barbaraca
• dc.contributor.author Sanz, Ferranca
• dc.contributor.author Fernández Fuentes, Narcísca
• dc.contributor.author Furlong, Laura I., 1971-ca
• dc.contributor.author Oliva Miguel, Baldomeroca
• dc.date.accessioned 2017-10-25T10:54:10Z
• dc.date.available 2017-10-25T10:54:10Z
• dc.date.issued 2017
• dc.description.abstract Understanding relationships between diseases, such as comorbidities, has important socio-economic implications, ranging from clinical study design to health care planning. Most studies characterize disease comorbidity using shared genetic origins, ignoring pathway-based commonalities between diseases. In this study, we define the disease pathways using an interactome-based extension of known disease-genes and introduce several measures of functional overlap. The analysis reveals 206 significant links among 94 diseases, giving rise to a highly clustered disease association network. We observe that around 95% of the links in the disease network, though not identified by genetic overlap, are discovered by functional overlap. This disease network portraits rheumatoid arthritis, asthma, atherosclerosis, pulmonary diseases and Crohn’s disease as hubs and thus pointing to common inflammatory processes underlying disease pathophysiology. We identify several described associations such as the inverse comorbidity relationship between Alzheimer’s disease and neoplasms. Furthermore, we investigate the disruptions in protein interactions by mapping mutations onto the domains involved in the interaction, suggesting hypotheses on the causal link between diseases. Finally, we provide several proof-of-principle examples in which we model the effect of the mutation and the change of the association strength, which could explain the observed comorbidity between diseases caused by the same genetic alterations.
• dc.description.sponsorship Authors acknowledge support of Spanish Ministry of Economy MINECO grant BIO2014-57518-R, Instituto Carlos III (ISCIII) FEDER grants CP10/00524 and PI13/00082, and EU H2020 Programme 2014-2020 under grant agreement no. 634143 (MedBioinformatics). CRP is supported by Spanish Ministry of Economy and Competitiveness FPI fellowship (BES2013063354). EG is supported by EU cofounded AGAUR Beatriu de Pinos fellowship from Government of Catalunya. The Research Programme on Biomedical Informatics (GRIB) is member of the Spanish National Bioinformatics Institute (INB) and PRB2-ISCIII, supported by grant PT13/0001/0023 of the PE I+D+I 2013-2016 funded by ISCII-FEDER.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Rubio-Perez C, Guney E, Aguilar D, Piñero J, Garcia-Garcia J, Iadarola B et al. Genetic and functional characterization of disease associations explains comorbidity. Sci Rep. 2017 Jul 24;7(1):6207. DOI: 10.1038/s41598-017-04939-4
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-017-04939-4
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/33092
• dc.language.iso eng
• dc.publisher Nature Publishing Groupca
• dc.relation.ispartof Scientific Reports. 2017 Jul 24;7(1):6207
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634143
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BIO2014-57518-R
• dc.rights © The Author(s) 2017. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Molecular medicine
• dc.subject.keyword Predictive medicine
• dc.subject.keyword Data mining
• dc.subject.keyword Network topology
• dc.subject.keyword Systems analysis
• dc.title Genetic and functional characterization of disease associations explains comorbidityca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion