Macrophage plasticity and the role of inflammation in skeletal muscle repair
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Kharraz, Yacineca
- dc.contributor.author Guerra, Joanca
- dc.contributor.author Mann, Christopher J.ca
- dc.contributor.author Serrano, Antonio L.ca
- dc.contributor.author Muñoz Cánoves, Pura, 1962-ca
- dc.date.accessioned 2015-04-01T07:06:58Z
- dc.date.available 2015-04-01T07:06:58Z
- dc.date.issued 2013ca
- dc.description.abstract Effective repair of damaged tissues and organs requires the coordinated action of several cell types, including infiltrating inflammatory cells and resident cells. Recent findings have uncovered a central role for macrophages in the repair of skeletal muscle after acute damage. If damage persists, as in skeletal muscle pathologies such as Duchenne muscular dystrophy (DMD), macrophage infiltration perpetuates and leads to progressive fibrosis, thus exacerbating disease severity. Here we discuss how dynamic changes in macrophage populations and activation states in the damaged muscle tissue contribute to its efficient regeneration. We describe how ordered changes in macrophage polarization, from M1 to M2 subtypes, can differently affect muscle stem cell (satellite cell) functions. Finally, we also highlight some of the new mechanisms underlying macrophage plasticity and briefly discuss the emerging implications of lymphocytes and other inflammatory cell types in normal versus pathological muscle repair.en
- dc.description.sponsorship Funding from MICINN (SAF2009-09782, FIS-PS09/01267, SAF2012-38547, PLE2009-0124, and CIBERNED), AFM, Fundación Marató-TV3, MDA, EU-FP7 (Myoage, Optistem, and Endostem). Y. Kharraz was supported by a postdoctoral fellowship from AFMen
- dc.format.mimetype application/pdfca
- dc.identifier.citation Kharraz Y, Guerra J, Mann CJ, Serrano AL, Muñoz-Cánoves P. Macrophage plasticity and the role of inflammation in skeletal muscle repair. Mediators of Inflammation. 2013;2013:491497. DOI: 10.1155/2013/491497ca
- dc.identifier.doi http://dx.doi.org/10.1155/2013/491497
- dc.identifier.issn 0962-9351ca
- dc.identifier.uri http://hdl.handle.net/10230/23325
- dc.language.iso engca
- dc.publisher Hindawica
- dc.relation.ispartof Mediators of Inflammation. 2013;2013:491497
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2009-09782
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-38547
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/PLE2009-0124
- dc.rights Copyright © 2013 Yacine Kharraz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/3.0/
- dc.subject.other Teixits -- Remodelacióca
- dc.subject.other Cèl·lules mareca
- dc.title Macrophage plasticity and the role of inflammation in skeletal muscle repairen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca