CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer
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- dc.contributor.author Hardwick, Marc
- dc.contributor.author Nolan, Luke
- dc.contributor.author Nicoll, James A.R.
- dc.contributor.author Jogai, Sanjay
- dc.contributor.author Arriola Aperribay, Edurne
- dc.contributor.author Joseph-Pietras, Debora
- dc.contributor.author Norman, Jeanette
- dc.contributor.author Ottensmeier, Christian H.H.
- dc.contributor.author Galea, Ian
- dc.date.accessioned 2022-07-04T06:33:53Z
- dc.date.available 2022-07-04T06:33:53Z
- dc.date.issued 2022
- dc.description.abstract We report a rapidly progressive and fatal CD8 T-cell-mediated cerebellitis after ipilimumab (cytotoxic T-lymphocyte-associated protein 4 inhibitor) for small cell lung cancer. Clinical features and histopathology were consistent with an accelerated form of paraneoplastic cerebellar degeneration. A patchy CD8 T-cell infiltrate spatially corresponded to areas of Purkinje cell loss, with occasional CD8 polarisation towards Purkinje cells. CD20-positive B cells were sparse. CD8 T-cell-mediated cerebellitis after immune checkpoint inhibitor treatment may recapitulate the early stages of paraneoplastic cerebellar degeneration.
- dc.format.mimetype application/pdf
- dc.identifier.citation Hardwick M, Nolan L, Nicoll JAR, Jogai S, Arriola E, Joseph-Pietras D, et al. CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer. Neuropathol Appl Neurobiol. 2022 Feb; 48(2): e12755. DOI: 10.1111/nan.12755
- dc.identifier.doi http://dx.doi.org/10.1111/nan.12755
- dc.identifier.issn 0305-1846
- dc.identifier.uri http://hdl.handle.net/10230/53670
- dc.language.iso eng
- dc.publisher Wiley
- dc.rights This is an open access article under the terms of the Creative Commons Attribution License, http://creativecommons.org/licenses/by/4.0/which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword CD8 T cells
- dc.subject.keyword CTLA-4 inhibitor
- dc.subject.keyword Cerebellitis
- dc.subject.keyword Immune checkpoint inhibitors
- dc.subject.keyword Ipilimumab
- dc.subject.keyword Paraneoplastic cerebellar degeneration
- dc.title CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion