Human Pharmacology of Mephedrone in Comparison with MDMA.
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- dc.contributor.author Papaseit Fontanet, Estherca
- dc.contributor.author Pérez Mañá, Claraca
- dc.contributor.author Mateus Rodriguez, Julian Andrésca
- dc.contributor.author Pujadas Bastardes, Mitonaca
- dc.contributor.author Fonseca Casals, Francina, 1972-ca
- dc.contributor.author Torrens, Martaca
- dc.contributor.author Olesti Muñoz, Eulàlia, 1991-ca
- dc.contributor.author Torre Fornell, Rafael de laca
- dc.contributor.author Farré Albaladejo, Magíca
- dc.date.accessioned 2016-10-06T10:58:43Z
- dc.date.issued 2016
- dc.description.abstract Mephedrone (4-methylmethcathinone) is a novel psychoactive substance popular among drug users because it displays similar effects to MDMA (3,4-methylenedioxymethamphetamine, ecstasy). Mephedrone consumption has been associated with undesirable effects and fatal intoxications. At present, there is no research available on its pharmacological effects in humans under controlled and experimental administration. This study aims to evaluate the clinical pharmacology of mephedrone and its relative abuse liability compared with MDMA. Twelve male volunteers participated in a randomized, double-blind, crossover, and placebo-controlled trial. The single oral dose conditions were: mephedrone 200 mg, MDMA 100 mg, and placebo. Outcome variables included physiological, subjective, and psychomotor effects, and pharmacokinetic parameters. The protocol was registered in ClinicalTrials.gov (NCT02232789). Mephedrone produced a significant increase in systolic and diastolic blood pressure, heart rate, and pupillary diameter. It elicited stimulant-like effects, euphoria, and well-being, and induced mild changes in perceptions with similar ratings to those observed after MDMA administration although effects peaked earlier and were shorter in duration. Maximal plasma concentration values for mephedrone and MDMA peaked at 1.25 h and 2.00 h, respectively. The elimination half-life for mephedrone was 2.15 h and 7.89 h for MDMA. In a similar manner to MDMA, mephedrone exhibits high abuse liability. Its earlier onset and shorter duration of effects, probably related to its short elimination half-life, could explain a more compulsive pattern of use as described by the users.ca
- dc.description.sponsorship Funding is supported in part by grants from Instituto de Salud Carlos III (ISCIII, FIS-FEDER, PI11/01961), ISCIIIRed de Trastornos Adictivos (RTA RD12/0028/0009), and The European Commission (Drug Prevention and Information Programme 2014–16, Contract no. JUST/2013/ DPIP/AG/4823, EU-MADNESS project and Drugs Policy Initiatives, Justice Programme 2014-2020, Contract no.HOME/2014/JDRU/AG/DRUG/7082, PREDICT Project). EP has a Rio Hortega fellowship (ISC-III, CM13/00016) and CP-M has a Juan Rodes fellowship (ISC-III, JR15/00005).
- dc.format.mimetype application/pdfca
- dc.identifier.citation Papaseit E, Pérez-Mañá C, Mateus JA, Pujadas M, Fonseca F. Human Pharmacology of Mephedrone in Comparison with MDMA. Neuropsychopharmacology. 2016 Oct;41(11):2704-13. DOI: 10.1038/npp.2016.75ca
- dc.identifier.doi http://dx.doi.org/10.1038/npp.2016.75
- dc.identifier.issn 0893-133X
- dc.identifier.uri http://hdl.handle.net/10230/27391
- dc.language.iso engca
- dc.publisher Nature Publishing Groupca
- dc.relation.ispartof Neuropsychopharmacology. 2016 Oct;41(11):2704-13
- dc.rights © Nature Publishing Group. http://dx.doi.org/10.1038/npp.2016.75ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Psicofàrmacsca
- dc.subject.other Farmacologiaca
- dc.title Human Pharmacology of Mephedrone in Comparison with MDMA.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca