RNA-protein interactions: central players in coordination of regulatory networks

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• dc.contributor.author Armaos, Alexandros, 1989-
• dc.contributor.author Zacco, Elsa
• dc.contributor.author Sanchez de Groot, Natalia
• dc.contributor.author Tartaglia, Gian Gaetano
• dc.date.accessioned 2021-03-17T09:56:22Z
• dc.date.available 2021-03-17T09:56:22Z
• dc.date.issued 2021
• dc.description.abstract Changes in the abundance of protein and RNA molecules can impair the formation of complexes in the cell leading to toxicity and death. Here we exploit the information contained in protein, RNA and DNA interaction networks to provide a comprehensive view of the regulation layers controlling the concentration-dependent formation of assemblies in the cell. We present the emerging concept that RNAs can act as scaffolds to promote the formation ribonucleoprotein complexes and coordinate the post-transcriptional layer of gene regulation. We describe the structural and interaction network properties that characterize the ability of protein and RNA molecules to interact and phase separate in liquid-like compartments. Finally, we show that presence of structurally disordered regions in proteins correlate with the propensity to undergo liquid-to-solid phase transitions and cause human diseases. Also see the video abstract here https://youtu.be/kfpqibsNfS0.
• dc.description.sponsorship The research leading to these results has been supported by European Research Council (RIBOMYLOME_309545 and ASTRA_855923), the H2020 projects IASIS_727658 and INFORE_825080, the Spanish Ministry of Economy and Competitiveness BFU2017‐86970‐P, the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie grant agreement No 754490 within the MINDED project.We also acknowledge support of the Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa and the CERCA Programme/Generalitat de Catalunya
• dc.format.mimetype application/pdf
• dc.identifier.citation Armaos A, Zacco E, Sanchez de Groot N, Tartaglia GG. RNA-protein interactions: central players in coordination of regulatory networks. Bioessays. 2021 Feb;43(2):e2000118. DOI: 10.1002/bies.202000118
• dc.identifier.doi http://dx.doi.org/10.1002/bies.202000118
• dc.identifier.issn 0265-9247
• dc.identifier.uri http://hdl.handle.net/10230/46818
• dc.language.iso eng
• dc.publisher Wiley-VCH Verlag
• dc.relation.ispartof Bioessays. 2021 Feb;43(2):e2000118
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/727658
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825080
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/855923
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/754490
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/309545
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017‐86970‐P
• dc.relation.projectID https://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.rights © 2020 Alexandros Armaos et al. BioEssays published by Wiley Periodicals LLC.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Genètica
• dc.subject.other Proteïnes
• dc.subject.other RNA
• dc.title RNA-protein interactions: central players in coordination of regulatory networks
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion