Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC* prospective study
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- dc.contributor.author Deza Vargas, Luis Gustavoca
- dc.contributor.author García-Bravo, Begoñaca
- dc.contributor.author Silvestre Salvador, Juan Franciscoca
- dc.contributor.author Pastor-Nieto, Maríaca
- dc.contributor.author González-Pérez, Ricardoca
- dc.contributor.author Heras-Mendaza, Felipeca
- dc.contributor.author Mercader, Pedroca
- dc.contributor.author Fernández-Redondo, Virginiaca
- dc.contributor.author Niklasson, B.ca
- dc.contributor.author Giménez Arnau, Anna Mariaca
- dc.contributor.author GEIDACca
- dc.date.accessioned 2017-12-19T08:21:12Z
- dc.date.issued 2017
- dc.description.abstract BACKGROUND: Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens. OBJECTIVES: To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim-OOHs) and hydroperoxides of linalool (Lin-OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients. METHODS: Three different concentrations of Lim-OOHs (0.1%, 0.2% and 0.3% pet.) and Lin-OOHs (0.25%, 0.5% and 1.0% pet.) were simultaneously tested in 3639 consecutive patients at 22 departments of dermatology in Spain. RESULTS: Lim-OOHs at 0.1%, 0.2% and 0.3% yielded positive patch test reactions in 1.4%, 3.4% and 5.1% of the tested patients, respectively; and Lin-OOHs at 0.25%, 0.5% and 1.0% yielded positive reactions in 1.3%, 2.9% and 4.9% of the tested patients, respectively. Few irritant (1.5-1.9%) and doubtful reactions (0.4-0.5%) to both terpene hydroperoxides were registered at the highest concentrations tested. CONCLUSIONS: Lim-OOHs and Lin-OOHs can be considered as common causes of contact allergy, and their inclusion in an extended baseline patch test series therefore seems to be appropriate. The patch test preparations of Lim-OOHs 0.3% pet. and Lin-OOHs 1.0% pet. are useful tools for screening of contact sensitization.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Deza G, García-Bravo B, Silvestre JF, Pastor-Nieto MA, González-Pérez R, Heras-Mendaza F. et al. Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC* prospective study. Contact Dermatitis. 2017 Feb;76(2):74-80. DOI: 10.1111/cod.12714
- dc.identifier.doi http://dx.doi.org/10.1111/cod.12714
- dc.identifier.issn 0105-1873
- dc.identifier.uri http://hdl.handle.net/10230/33527
- dc.language.iso eng
- dc.publisher Wileyca
- dc.relation.ispartof Contact Dermatitis. 2017 Feb;76(2):74-80
- dc.rights This is the peer reviewed version of the following article: Deza G, García-Bravo B, Silvestre JF, Pastor-Nieto MA, González-Pérez R, Heras-Mendaza F. et al. Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC* prospective study. Contact Dermatitis. 2017 Feb;76(2):74-80, which has been published in final form at http://dx.doi.org/10.1111/cod.12714. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Allergic contact dermatitis
- dc.subject.keyword Fragrance allergy
- dc.subject.keyword Hydroperoxides
- dc.subject.keyword Limonene
- dc.subject.keyword Linalool
- dc.subject.other Dermatitis de contacte
- dc.subject.other Política de drogas ilegales en España
- dc.title Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC* prospective studyca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion